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Deconstructing Psychosis

Refining the Research Agenda for DSM-V

Carol A. Tamminga, M.D., Paul J. Sirovatka, M.S., Darrel A. Regier, M.D., M.P.H., and Jim van Os, M.D., Ph.D.

  • ISBN 978-0-89042-653-1
  • Item #2653

Description

Deconstructing Psychosis: Refining the Research Agenda for DSM-V provides an all-important summary of the latest research about the diagnosis and pathophysiology of psychosis. This volume gives the reader an inside look at how psychotic phenomena are represented in the current diagnostic system and how DSM-V might better address the needs of patients with such disorders.

The book presents a selection of papers reporting the proceedings of a conference titled “Deconstructing Psychosis” convened by the American Psychiatric Association (APA) in collaboration with the World Health Organization (WHO) and the U.S. National Institutes of Health (NIH). The conference was designed to be a key element in the multiphase research review process for the fifth revision of DSM. This book is one in a series of ten that reflects some of the most current and critical examinations of psychiatric disorders and psychotic syndromes. APA published the fourth edition of DSM in 1994 and a text revision in 2000. DSM-V is scheduled for publication in 2013.

Deconstructing Psychosis: Refining the Research Agenda for DSM-V examines the current evidence regarding the diagnosis and pathophysiology of common psychotic syndromes including:

  • Schizophrenia
  • Bipolar disorder
  • Major depressive psychosis
  • Substance-induced psychosis

It also addresses broad issues relating to diagnosis such as the ways in which psychosis cuts across multiple diagnostic categories. Beyond merely summarizing the current state of the science, the authors of these papers critique the current research and clinical evidence, and raise questions about gaps in our knowledge.

The book provides recommendations for the most promising areas of research in psychosis, which may lead to more refined treatments based on a better understanding of what biological and environmental factors contribute to its development and symptoms.

In the learned editors’ selection of papers for inclusion in this volume, they have exhibited their conviction that DSM-V is a “living document” that will reflect the pace of progress in multiple areas, ranging from molecular genetics and brain imaging to social, behavioral, and anthropological science.

As a book on the narrowly defined topic of linking the classification of psychotic syndromes with their underlying pathophysiology and potential etiology, there is no other writing of comparable content available today.

Contents

CONTRIBUTORS
DISCLOSURE STATEMENT
FOREWORD: Rethinking Psychosis in DSM-V
INTRODUCTION
Chapter 1. DECONSTRUCTING PSYCHOSIS CONFERENCE FEBRUARY 2006: The Validity of Schizophrenia and Alternative Approaches to the Classification of Psychosis
Chapter 2. BIOLOGICAL, LIFE COURSE, AND CROSS-CULTURAL STUDIES ALL POINT TOWARD THE VALUE OF DIMENSIONAL AND DEVELOPMENTAL RATINGS IN THE CLASSIFICATION OF PSYCHOSIS
Chapter 3. CURRENT ISSUES IN THE CLASSIFICATION OF PSYCHOTIC MAJOR DEPRESSION
Chapter 4. DECONSTRUCTING BIPOLAR DISORDER: A Critical Review of Its Diagnostic Validity and a Proposal for DSM-V and ICD-1
Chapter 5. DSM-V RESEARCH AGENDA: Substance Abuse/Psychosis Comorbidity
Chapter 6. THE GENETIC DECONSTRUCTION OF PSYCHOSIS
Chapter 7. HOW SHOULD DSM-V CRITERIA FOR SCHIZOPHRENIA INCLUDE COGNITIVE IMPAIRMENT?
Chapter 8. SEARCHING FOR UNIQUE ENDOPHENOTYPES FOR SCHIZOPHRENIA AND BIPOLAR DISORDER WITHIN NEURAL CIRCUITS AND THEIR MOLECULAR REGULATORY MECHANISMS
Chapter 9. DECONSTRUCTING PSYCHOSIS WITH HUMAN BRAIN IMAGING
Chapter 10. IDENTIFYING FUNCTIONAL NEUROIMAGING BIOMARKERS OF BIPOLAR DISORDER: Toward DSM-V
Chapter 11. THE NEUROPHARMACOLOGY OF PSYCHOSIS
INDEX

About the Authors

Carol A. Tamminga, M.D., is a Professor of Psychiatry and Interim Chair of the Department of Psychiatry at the University of Texas Southwestern Medical Center in Dallas, Texas.

Paul J. Sirovatka, M.S., (1947-2007), was Director of Research Policy Analysis at the Division of Research and American Psychiatric Institute for Research and Education at the American Psychiatric Association.

Darrel A. Regier, M.D., M.P.H., is Executive Director of the American Psychiatric Institute for Research and Education and Director of the Division of Research at the American Psychiatric Association in Arlington, Virginia.

Jim van Os, M.D., Ph.D., is a Professor of Psychiatric Epidemiology in the Department of Psychiatry and Neuropsychology at the South Limburg Mental Health Research and Teaching Network, European Graduate School for Neuroscience at Maastricht University in Maastricht, The Netherlands; and Visiting Professor of Psychiatric Epidemiology in the Division of Psychological Medicine at the Institute of Psychiatry in London, England.

Shining new light on our traditional diagnostic framework for psychotic disorders, this collection of papers brings together authoritative and incisive views from around the globe. Deconstructing Psychosis represents just one step in the long path of DSM-V deliberations that began over a decade ago. This path may lead to greater validity of our diagnostic constructs through careful development of complementary categorical and dimensional representations of psychotic disorders as well as the integration of emerging knowledge from areas such as genetics, neuroimaging and cognitive neuroscience.—Susan K. Schultz, M.D., University of Iowa Carver College of Medicine, Iowa City, Iowa


If a paradigm shift is accomplished with DSM-V, it will be based on identifying meaningful pathological domains within syndromes. This book, with a terrific group of authors, provides the basis for deconstructing psychotic syndromes.—William T. Carpenter Jr., M.D., Professor of Psychiatry and Pharmacology, University of Maryland School of Medicine, Director of Maryland Psychiatric Research Center

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