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The American Psychiatric Publishing Textbook of Schizophrenia

Edited by Jeffrey A. Lieberman, M.D., T. Scott Stroup, M.D., M.P.H., and Diana O. Perkins, M.D., M.P.H.

  • ISBN 978-1-58562-191-0
  • Item #62191


Although there are many books that consider aspects of schizophrenia such as research or clinical care, now there is a single resource that puts the many facets of this widely misunderstood disorder in perspective. The American Psychiatric Publishing Textbook of Schizophrenia offers broad coverage that encompasses the current state of knowledge the cause, nature, and treatment of schizophrenia. Experts in a wide range of disciplines from North America and Europe have contributed chapters that address the complexity of schizophrenia in a comprehensive volume on this singularly perplexing mental illness.

No disorder is more challenging to psychiatrists and mental health care providers than schizophrenia, a condition that robs people of their personality and intellect and leaves them permanently disabled. This book leads readers through the maze of questions surrounding the disorder, from historical overview and epidemiology to consideration of comorbid conditions. It covers both genetic and environmental causes, describes all of the leading theories of schizophrenia—neurodevelopmental, neurochemical, phospholipid, and neuroprogressive—and explores the involvement of abnormal brain circuitry and the results of the latest neuroimaging studies. For practicing clinicians, the topics covered represent the most essential, timely, and informative insights for treating this most prototypic of mental illnesses:

  • Approaching cognitive impairment as a potential psychopharmacological target for treatment, plus treatment strategies for improving functioning in individuals with social or vocational impairment.
  • An overview of selected antipsychotic drugs—including common side effects—as well as antianxiety/hypnotics, antidepressants, mood stabilizers, and dopamine agonists.
  • A review of current proven psychosocial interventions designed to augment and complement drug therapy, highlighting the trend toward optimizing patient preference in the choice of treatment modality.
  • Keys to early identification of individuals vulnerable to psychoses and to assessing the potential for intervention with the promise of treatment earlier in life.
  • Optimal treatment approaches for first episodes—including individual, group, and family therapies—to increase the likelihood of full recovery.
  • Special considerations for treatment of chronic schizophrenia, addressing frequently asked questions faced by psychiatrists in their daily encounters with patients.

While its causes and cure remain elusive, schizophrenia can be better understood with the help of the authoritative knowledge collected in these pages. Squarely confronting a disease that has long afflicted and baffled human society, this textbook will serve as a dependable source of knowledge for a generation of students, scientists, and clinicians to come.


Chapter 1. History of Schizophrenia and Its Antecedents
Chapter 2. Epidemiology
Chapter 3. Genetics
Chapter 4. Prenatal and Perinatal Factors
Chapter 5. Neurodevelopmental Theories
Chapter 6. Neurochemical Theories
Chapter 7. Phospholipids in Schizophrenia
Chapter 8. Neuroprogressive Theories
Chapter 9. Neuropathology and Neural Circuits Implicated in Schizophrenia
Chapter 10. Structural and Functional Neuroanatomy
Chapter 11. Psychopathology
Chapter 12. Co-occurring Substance Use and Other Psychiatric Disorders
Chapter 13. Neurocognitive Impairments
Chapter 14. Social Cognitive Impairments
Chapter 15. Social and Vocational Impairments
Chapter 16. Natural History and Predictors of Clinical Course
Chapter 17. Pharmacotherapies
Chapter 18. Psychosocial Therapies
Chapter 19. The Prodrome
Chapter 20. First Episode
Chapter 21. Treatment of Chronic Schizophrenia
Chapter 22. Nonpsychiatric Comorbid Disorders
Chapter 23. Treatment of Schizophrenia in the Public Sector


Jean Addington, Ph.D.
Nancy C. Andreasen, M.D., Ph.D.
Aysenil Belger, Ph.D.
Mary F. Brunette, M.D.
William T. Carpenter, Jr., M.D.
Chuan-Yu Chen, Ph.D.
Gabriel Dichter, Ph.D.
Vaibhav A. Diwadkar, Ph.D.
Lisa Dixon, M.D., M.P.H.
Robert E. Drake, M.D., Ph.D.
William W. Eaton, Ph.D.
Charles E. Eesley, B.S.
Wayne S. Fenton, M.D.
Robert Freedman, M.D.
Andrew R. Gilbert, M.D.
John H. Gilmore, M.D.
Shirley M. Glynn, Ph.D.
Alan I. Green, M.D.
Raquel Gur, M.D., Ph.D.
L. Fredrik Jarskog, M.D.
Daniel C. Javitt, M.D., Ph.D.
Dilip V. Jeste, M.D.
Richard S. E. Keefe, Ph.D.
Matcheri S. Keshavan, M.D.
Anzalee Khan, M.S.
John E. Kraus, M.D., Ph.D.
Marc Laruelle, M.D.
John Lauriello, M.D.
Anthony F. Lehman, M.D., M.S.P.H.
David A. Lewis, M.D.
Shon Lewis, M.D.
Jeffrey A. Lieberman, M.D.
J. P. Lindenmayer, M.D.
Sahebarao P. Mahadik, Ph.D.
Stephen R. Marder, M.D.
Joseph McEvoy, M.D.
Thomas H. McGlashan, M.D.
Susan R. McGurk, Ph.D.
Erick Messias, M.D., M.P.H., Ph.D.
Alexander L. Miller, M.D.
Lydia Miller-Andersen, M.D.
Kim T. Mueser, Ph.D.
Robin M. Murray, M.D.
Douglas L. Noordsy, M.D.
Michael C. O'Donovan, Ph.D., F.R.C.Psych.
Michael J. Owen, Ph.D., F.R.C.Psych., F.Med.Sci.
David L. Penn, Ph.D
Diana O. Perkins, M.D., M.P.H.
Amy Pinkham, M.A.
Trevor W. Robbins, Ph.D.
Michael H. Stone, M.D.
T. Scott Stroup, M.D., M.P.H.
Patrick F. Sullivan, M.D., F.R.A.N.Z.C.P.
Marvin S. Swartz, M.D.
Carol A. Tamminga, M.D.
Ming T. Tsuang, M.D.
Elizabeth M. Tully, M.D.
Karen Wohlheiter, M.S.
Jeffrey K. Yao, Ph.D., FACB

About the Authors

Jeffrey A. Lieberman, M.D., is Chairman of the Department of Psychiatry at the College of Physicians and Surgeons of Columbia University; Director of the New York State Psychiatric Institute; Director of the Lieber Center for Schizophrenia Research; and Psychiatrist-in-Chief at New York Presbyterian Hospital and Columbia University Medical Center in New York City.

T. Scott Stroup, M.D., M.P.H., is Associate Professor in the Department of Psychiatry at the University of North Carolina at Chapel Hill.

Diana O. Perkins, M.D., M.P.H., is Professor of Psychiatry at the University of North Carolina School of Medicine in Chapel Hill.

Understanding schizophrenia is psychiatry's leading challenge. In this textbook, foremost scholars review current concepts and knowledge, bringing together the many pieces of the puzzle. This is a terrific single source on issues ranging from the history of the concept, through etiology and pathology, to psychosocial and pharmacologic treatments. Special issues such as comorbidity, first-episode patients, and clinical care in the public sector are addressed.—William T. Carpenter Jr., M.D., Professor of Psychiatry and Pharmacology, University of Maryland School of Medicine; Director, Maryland Psychiatric Research Center, Baltimore, Maryland

Since Benedict Morel first established the diagnostic category of dementia praecox in 1860, each generation has attempted to characterize in its own terms the central disorder of psychiatry. Thus, in 1893 Emil Kraepelin distinguished dementia praecox from manic-depressive illness in descriptive terms, in 1911 Eugen Bleuler provided a dynamic perspective and renamed the illness schizophrenia, and in the 1960s Arvid Carlsson gave us the first biochemical insights into the disorder. Lieberman, Stroup, and Perkins now provide us with the textbook that will mark this generation. Their book is a must for every psychiatrist who wants to understand where modern research and clinical practice now stand, and where it needs to go in the next decade to ameliorate the suffering of patients with schizophrenia and their families. Taking a broad, scholarly, and synthetic approach to schizophrenia, this remarkable book outlines our understanding of how specific candidate genes can interact with environmental stressors to give rise to anatomical alterations during development that lead to the family of symptoms that characterize the disorder.—Eric R. Kandel, M.D., Kavli Prof & Director, Kavli Inst Brain Sci; Senior Investigator, Hughes Med Inst Ctr for Neurobiology & Behavior, Dept of Psychiatry, Biochemistry &Physiology, Columbia Univ

Its comprehensiveness makes it unique as a single source of up-to-date information that can be recommended to patients, advocates, clinicians, and researchers. Moreover, the textbook is evidence-based. Contributors are clear as to the nature of the data from which conclusions are drawn, distinguishing among untested hypotheses, vignettes, studies with major limitations and flaws, and rigorous, carefully designed work. . . . Most readers will find it refreshing and helpful to find both pragmatic information that can be applied in treating patients today alongside information indicating the limits of our knowledge and suggesting where research needs to focus. . . . The American Psychiatric Publishing Textbook of Schizophrenia is arguably the best single source for information.—JAMA, 6/28/2006

Companion Products

Essentials of Schizophrenia

Jeffrey A. Lieberman, M.D., T. Scott Stroup, M.D., M.P.H., and Diana O. Perkins, M.D., M.P.H. 2012

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