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Molecular Neurobiology for the Clinician

Edited by Dennis S. Charney, M.D.
Series Editors: John M. Oldham, M.D., M.S., and Michelle B. Riba, M.D., M.S.

  • ISBN 978-1-58562-113-2
  • Item #62113

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In this authoritative volume you'll find today's most important molecular neurobiological advances and their relevance to clinicians treating patients with mental illness. Molecular Neurobiology for the Clinician, Review of Psychiatry, Volume 22, will update you on the latest findings—and their impact on psychiatry.

You'll learn about

  • Discoveries with the potential to revolutionize your clinical approach by changing the ways in which you diagnose and treat patients
  • The effects on psychiatry of advances in the molecular basis of neuronal network function, particularly in relation to abnormalities in cognitive and emotional regulation, and the identification of novel molecular targets for drug development
  • How to apply these discoveries to diagnosing and treating major psychiatric disorders, including childhood- and adolescent-onset disorders, schizophrenia, drug addiction, and severe mood and anxiety disorders

Molecular Neurobiology for the Clinician is an outstanding compilation of the best research by top names in the field. Psychiatrists, psychologists, psychiatric residents, and graduate students in neuroscience, psychiatry, and psychology will gain knowledge, understanding, and techniques for better diagnosis and treatment.


  • Contributors
  • Introduction to the Review of Psychiatry Series
  • Preface
  • Chapter 1. Molecular neurobiology of childhood- and adolescent-onset psychiatric disorders
  • Chapter 2. Molecular genetics: a role in diagnosis and treatment of psychiatric disorders?
  • Chapter 3. Molecular neurobiology and schizophrenia: implications for etiology and treatment
  • Chapter 4. Molecular mechanisms of drug addiction
  • Chapter 5. Cellular neurobiology of severe mood and anxiety disorders: implications for development of novel therapeutics
  • Index

About the Authors

Dennis S. Charney, M.D., is Chief of the Mood and Anxiety Disorders Program, and Chief of the Experimental Therapeutics and Pathophysiology Branch, at the National Institute of Mental Health in Bethesda, Maryland.

This multiauthor text explores the current state of knowledge of molecular abnormalities in psychiatric disorders. The book does an outstanding job of illustrating the interface between basic science and clinical psychiatry. . . . The authors artfully integrate what is known about genetics and neurochemistry with diagnosis and treatment of several psychiatric disorders.—Michael Garvey, M.D., The American Journal of Psychiatry, 6/1/2004

This is an outstanding book by the best investigators in the field. It is concise and lucid. It articulates the emerging neurosciences in a clear and precise fashion. Dr. Cook's chapter on childhood disorders is well written. It captures the excitement in the field. Highlights recent discoveries and puts them into context. Chapter 2 by Dr. McMahon highlights work in schizophrenia and bipolar disorder. This chapter examines recent strategies. Dr. Lewis provides a remarkably clear exposition of recent molecular and neurobiological findings in schizophrenia. Dr. Nestler's chapter as well as the chapters by Dr. Manji are the best expositions on neurobiology of drug addition, reward, mood and anxiety that I have seen. In all this is a remarkable book that will serve as a foundation and a cornerstone in understanding molecular neurobiology for clinicians, training directors and residents. This should be required reading and a course book for psychiatry residents. Clinicians will find it to be a fascinating introduction to the neuroscience of mental disorders.—K. Ranga Rama Krishnan, Chairman, Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, Durham, North Carolina

This latest contribution by Dennis Charney and colleagues is a masterful tour-de-force of what is happening today in neuroscience relevant to psychiatry. The chapters are not only cutting-edge and informative, they are highly readable. Only Dr. Charney, with his command of both molecular biology and clinical investigation, could have assembled so distinguished a group of scientists to contribute to this excellent volume. Other scientists, clinicians, and students at all levels will find this book both enjoyable and stimulating.—Jack M. Gorman, M.D., Interim Chair, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York

Molecular Neurobiology for the Clinician by Dennis S. Charney M.D., is an extraordinary compendium of recent advances in neuroscience that begin to inform new theories regarding the pathophysiology of complex psychiatric disorders. Clinicians will find this volume relevant to their current practice and will gain clear appreciation for the future of psychiatry-diagnosis, treatment, and prevention of major mental illness.—Dwight L. Evans, M.D., Ruth Meltzer Professor and Chairman, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

This is a valuable book on the molecular neurobiology of psychiatric disorders. I highly recommend it to anyone interested in understanding psychiatric disorders.—Michael J. Schrift, DO., Doody's Book Reviews, 6/1/2004

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