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Managing the Side Effects of Psychotropic Medications, Second Edition

Joseph F. Goldberg, M.D., M.S., and Carrie L. Ernst, M.D.
Foreword by Stephen M. Stahl, M.D., Ph.D.

  • ISBN 978-1-61537-203-4
  • Item #37203

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Information about new psychotropic drugs, a summary of advances in knowledge about identifiable risk factors for adverse effects, and updated recommendations on viable antidote management strategies—including novel pharmacotherapies for tardive dyskinesia and newer agents for weight loss—are among the features of this new, second edition of Managing the Side Effects of Psychotropic Medications.

Where other psychopharmacology textbooks—and, indeed, most internships and residencies in psychiatry—lack a solid basis in primary care medicine, this guide bridges that educational gap, offering a thorough examination of all the effects of taking a psychotropic drug as well practical clinical advice on how to manage complications that arise.

The book is divided into three parts: The first deals with global issues that affect the assessment and formulation of possible adverse effects, as well as with pertinent concepts related to basic pharmacology, physiology, and medical monitoring. The second part presents information organized by individual organ systems or specific medical circumstances. The final part focuses on summary recommendations covering all the material presented in the book and is followed by helpful appendixes and self-assessment questions and resources for practitioners.

This new edition includes:

  • Updated summaries about what psychiatrists should know regarding drug-drug interactions, iatrogenic cardiac arrhythmias, drug pressor effects and orthostatic hypotension, and drug rashes; as well as updated discussions on avoiding lithium nephrotoxicity, handling adverse effect emergencies, and understanding new FDA classifications about drug safety during pregnancy
  • An expanded discussion on the strengths and limitations of pharmacogenetic testing to predict adverse drug effects, as well as information about new treatments for sexual dysfunction, sleep disturbances, cognitive complaints, and other maladies
  • Revised summary tables to aid rapid assessment and management
  • An expanded section on supplemental resources
  • An updated and expanded self-assessment section with more key questions

Busy clinicians will find in Managing the Side Effects of Psychotropic Medications an accessible reference that provides both scientific and scholarly discussion of the consequences of drug therapies they may prescribe (or avoid), the range of available strategies to effectively manage adverse effects, and the scientific and practical implications of their treatment decisions.


  • Foreword to the Second Edition
  • Preface
  • List of Abbreviations
  • List of Drugs
  • PART I: General Considerations
  • Chapter 1. The Psychiatrist as Physician
  • Chapter 2. Pharmacokinetics, Pharmacodynamics, and Pharmacogenomics
  • Chapter 3. Vulnerable Populations
  • Chapter 4. Adverse Psychiatric Effects of Nonpsychotropic Medications
  • Chapter 5. Adverse Psychiatric Effects of Psychiatric Medications
  • Chapter 6. What Nonmedical Therapists Should Know About Adverse Drug Effects
  • PART II: Organ Systems
  • Chapter 7. Cardiovascular System
  • Chapter 8. Dermatological System
  • Chapter 9. Ear, Nose, and Throat
  • Chapter 10. Electrolyte Abnormalities
  • Chapter 11. Endocrinopathies
  • Chapter 12. Gastrointestinal System
  • Chapter 14. Hematological System
  • Chapter 15. Metabolic Dysregulation and Weight Gain
  • Chapter 16. Musculoskeletal System
  • Chapter 17. Neurological System
  • Chapter 18. Ophthalmological System
  • Chapter 19. Sleep Disturbances
  • Chapter 20. Systemic Reactions
  • Chapter 21. Pregnancy and the Puerperium
  • Chapter 22. Emergency Situations
  • PART III: Summary Recommendations
  • Chapter 23. Summary Recommendations
  • Appendix 1: Summary of Major Adverse Effects and Monitoring/Management Considerations
  • Appendix 2: Self-Assessment Questions and Answers
  • Appendix 3: Resources for Practitioners
  • References
  • Index


    Debra Berman
    Deborah Tourtlotte
    Stephen M. Stahl, M.D., Ph.D.
    Ross J. Baldessarini, M.D.

About the Authors

Joseph F. Goldberg, M.D., M.S., is Clinical Professor of Psychiatry at the Icahn School of Medicine at Mount Sinai in New York, New York.

Carrie L. Ernst, M.D., is Associate Professor of Psychiatry and Medical Education at the Icahn School of Medicine at Mount Sinai in New York, New York.

Goldberg and Ernst have updated their very valuable text Managing Side Effects of Psychotropic Medications in this second edition and it is a very welcome addition to the busy practitioner's armamentarium. It provides in a single source important and often hard to find guidance on managing side effects of commonly (and uncommonly) prescribed psychiatric medications. It will be a very, very useful resource for psychiatrists, non-medically trained mental health professionals, nurses and students in a variety of fields. Their vast clinical experience is evident throughout the text.—Charles B. Nemeroff, M.D., Ph.D., Leonard M. Miller Professor and Chairman, Department of Psychiatry and Behavioral Sciences, Clinical Director, Center on Aging, Chief of Psychiatry, Jackson Memorial Hospital, Chief of Psychiatry, University of Miami Hospital, Professor of Biochemistry and Molecular Biology, Leonard M. Miller School of Medicine, University of Miami

This is an impressive work. It is a comprehensive, thorough, scholarly, detailed, and practical book for clinicians, a thoughtful balance of art and science. The result is a tour de force that belongs on the bookshelves of psychiatrists and many others.—Alan J. Gelenberg, M.D.

Managing the Side Effects of Psychotropic Medications, 2nd Edition, has uniquely combined the art and science, the pragmatic and theoretical, yet throughout remains organically accessible and acutely relevant to decisions and choices in the clinical ecosystem. This erudite book will be of tremendous interest, and a must have, for all healthcare providers of persons receiving psychotropic agents, students of all levels, as well as individuals who are academically interested/involved.—Roger S. McIntyre, M.D., FRCPC, Professor of Psychiatry and Pharmacology, University of Toronto, Toronto, Canada, Chairman and Executive Director, Brain and Cognition Discovery Foundation (BCDF), Toronto, Canada, Director, Depression and Bipolar Support Alliance (DBSA), Chicago, USA, Head, Mood Disorders Psychopharmacology Unit

This is an admirable work. It lays a solid foundation of pharmacological knowledge and then builds upon it by reviewing various organ systems. The chapters are clear, concise, and helpful. Readers can be confident that they will be able to identity and manage the various side effects that they will encounter. This is all accomplished without overwhelming readers, which can so often occur when exploring potential side effects of medications. I highly recommend this book. The second edition was necessary given the newer medications as well as the research findings that have emerged since the first edition.—Aaron Plattner, M.D., Doody's Book Reviews

As I wrote about the first edition, this is a comprehensive, well organized, and well written volume on a very important part of psychiatric practice. It includes a number of great (although at times overwhelming) tables summarizing the text. More attention (understandably) is paid to newer medications and their side effects. The cautiousness of some advice is understandable given the difficulty of balancing case reports and randomized studies (not many of which are focused on side effects). The book is not perfect (although close to it), but what book is perfect? As noted, there is nothing like this volume available on the market. If you do not have the first edition, you should buy this one. And if you have the first edition, you still should consider buying this one. It is worth the money.—Richard Balon, M.D.

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