Psychiatric disorders and medical illness are often comorbid. Psychopharmacological treatment thus poses several efficacy and safety challenges. This manual covers the main—if not all of—the needs that psychiatrists and medical specialists have in the psychopharmacological treatment of medical patients. It is extraordinary well documented, updated, and precise. The manual is both a very useful resource for the clinician and a clear educational tool for students. This second, enriched new edition promises an even better success than the previous one.—Prof. Massimo Biondi, M.D., Full Professor of Psychiatry, Director of Postgraduate School in Psychiatry, Department of Neurology and Psychiatry, SAPIENZA University of Rome

The first edition of this book was an instant must have for all psychiatrists, whether they treat patients with comorbid medical conditions or not. The second edition of the Manual is even better, updated and another must have book for all psychiatrists. The evidence supporting the use for or against a medication in a particular medical illness is reviewed succinctly. I particularly liked the Key Points at the end of each chapter as they provided a summary of the take home messages. Congratulations to the authors and editors for producing such a valuable textbook.—Philip R. Muskin, M.D., M.A., DLFAPA, Professor of Psychiatry at CUMC, Chief of Service: Consultation-Liaison Psychiatry, NYPH-Columbia Campus/Allen, Lawrence & Milstein Hospitals, Chair: APA2017 Scientific Program Committee

(This manual) is a timely, highly pragmatic, thorough, and essential volume for psychosomatic medicine (PSM). Thoughtfully dedicated to their late colleague and collaborator James Owen (who was an author on several chapters), the book takes a clinically and scientifically grounded approach to the myriad challenges of the management of co-morbid psychiatric and systemic illness. This volume should be available to every PSM psychiatry service and should also be of interest to the general psychiatrist who is expected to function in a PSM role on occasion.—James A. Bourgeois, O.D., M.D., Clinical Professor, Psychiatry, Weill Institute for Neurosciences, Department of Psychiatry/Langley Porter Psychiatric Institute, University of California, San Francisco, San Francisco, CA

As patients live longer medical comorbidity has become exceedingly common with various psychiatric disorders, including major depression and bipolar disorder. Indeed, some of our primary treatments for these disorders may actually lead to this comorbidity because of biological consequences of specific pharmacology agents. Thus, today we can no longer easily separate medical and psychiatric disorders in our approaches to specific patients. Indeed, a wider knowledge of the interface is needed for everyday practice. In this vein we need to consider medical status when prescribing psychotropic agents. The Second Edition of this Manual helps all of us to practice better and is a must read. Its first edition was an enormous step forward for the field and this Second Edition will only bring us further up to date on how best to prescribe psychotropic drugs in treating co-morbid patients.—Alan F. Schatzberg, M.D., Kenneth T. Norris, Jr., Professor, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine

This is a particularly useful tool for those in medical training. It is well organized by topic, with clear explanations and uncomplicated language. It also provides sufficient background information for each topic, starting with very basic concepts, making it ideal for those at the beginning of residency training. The charts and diagrams throughout the book are probably the strongest features. I tend to prefer online resources for day-to-day practice, given the ability to easily access them and the (possibly false) belief that they are more relevant or up to date than print resources. However, I will keep this book out, as its appendixes and tables are superior to what I have found in commonly used online sites. Also, the relevance to pharmacokinetic interactions and quick comparison to other medications would both require a more time-intensive search online to get a similar depth of information. I would highly recommend this book to anyone treating patients with psychiatric and medical comorbidities.—Shayna Bailey, M.D., Doody's Book Review