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Clinical Manual of Psychopharmacology in the Medically Ill, Third Edition

Edited by James L. Levenson, M.D., and Stephen J. Ferrando, M.D.

  • ISBN 978-1-61537-513-4
  • Item #37513

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With examinations of 19 new psychiatric drugs, 19 new forms of previously available drugs, and a host of new medical agents, this third edition of the Clinical Manual of Psychopharmacology in the Medically Ill has been updated to include medical and psychiatric drugs that have become available since the publication of the second edition in 2017, as well as recent relevant randomized controlled trials, systematic reviews, and meta-analyses.

Boasting all the rigor that characterized the preceding editions, every chapter in this new volume has been reviewed and revised by experts—including 11 new authors. For 15 categories of medical disorders and specialty areas that include cardiovascular disorders, oncology, obstetrics and gynecology, and substance use disorders, the book examines

  • Key differential diagnostic considerations
  • The evidence for the efficacy of psychiatric drugs in each disorder
  • Disease-specific side effects of psychiatric drugs
  • Neuropsychiatric side effects of drugs for each medical disorder
  • Disease-specific alterations in pharmacokinetics
  • Drug-drug interactions

Patients with medical and psychiatric comorbidity have more functional impairment, disability days, emergency department use, and rehospitalization, as well as higher medical care costs. By examining the intersection of psychiatric and medical illness, and offering easily referenced key points for each chapter, this new edition prepares both mental health practitioners and primary care physicians and internists to more safely and effectively work with patients who have psychiatric and medical illness.


  • Part I: General Principles
  • Chapter 1. Pharmacokinetics, Pharmacodynamics, and Principles of Drug-Drug Interactions
  • Chapter 2. Severe Drug Reactions
  • Chapter 3. Alternative Routes of Drug Administration
  • Part II: Psychopharmacology in Organ System Disorders and Specialty Areas
  • Chapter 4. Gastrointestinal Disorders
  • Chapter 5. Renal and Urological Disorders
  • Chapter 6. Cardiovascular Disorders
  • Chapter 7. Respiratory Disorders
  • Chapter 8. Oncology
  • Chapter 9. Central Nervous System Disorders
  • Chapter 10. Endocrine and Metabolic Disorders
  • Chapter 11. Obstetrics and Gynecology
  • Chapter 12. Infectious Diseases
  • Chapter 13. Dermatological Disorders
  • Chapter 14. Rheumatological Disorders
  • Chapter 15. Surgery and Critical Care
  • Chapter 16. Organ Transplantation
  • Chapter 17. Pain Management
  • Chapter 18. Substance Use Disorders


    Katie S. Adams, Pharm.D.
    Syed Rashdi Ahmed, M.D.
    Margaret Altemus, M.D.
    Rosalind M. Berkowitz, M.D.
    Philip A. Bialer, M.D.
    Jozef Bledowski, M.D.
    Melissa P. Bui, M.D.
    E. Cabrina Campbell, M.D.
    Jason P. Caplan, M.D.
    Stanley N. Caroff, M.D.
    Catherine C. Crone, M.D.
    Ericka L. Crouse, Pharm.D.
    Catherine Daniels-Brady, M.D.
    Elisabeth A. Dietrich, M.D.
    Andrea F. DiMartini, M.D.
    Andrew Drysdale, M.D., Ph.D.
    Stephen J. Ferrando, M.D.
    Marian Fireman, M.D.
    Madhulika A. Gupta, M.D., M.Sc., FRCPC
    Jennifer Kraker, M.D., M.S.
    Alba Lara, M.D.
    Jonathan G. Leung, Pharm.D.
    James L. Levenson, M.D.
    Stephan C. Mann, M.D.
    Michael Marcangelo, M.D.
    Curtis A. McKnight, M.D.
    Sahil Munjal, M.D.
    Mallay Occhiogrosso, M.D.
    Kimberly N. Olson, CRNP
    Jacqueline Posada, M.D.
    Peter A. Shapiro, M.D.
    Yvette L. Smolin, M.D.
    Cullen Truett, D.O.
    Christina M. van der Feltz-Cornelis, M.D., Ph.D.
    Robert M. Weinrieb, M.D., FACLP
    Shirley Qiong Yan, Pharm.D., BCOP

About the Authors

James L. Levenson, M.D., is Rhona Arenstein Professor of Psychiatry, Professor of Medicine and Surgery, Chair of the Division of Consultation-Liaison Psychiatry, and Vice-Chair in the Department of Psychiatry at Virginia Commonwealth University School of Medicine in Richmond, Virginia.

Stephen J. Ferrando, M.D., is Director of the Department of Psychiatry at Westchester Medical Center Health System and Edith Har Esh, M.D., Professor and Chairman in the Department of Psychiatry and Behavioral Sciences at New York Medical College in Valhalla, New York.

The use of psychoactive drugs in the medically ill is an important, complex, and often perplexing field. This reference book is correspondingly not only important but also superb in providing much needed guidance by describing both general principles and summarizing the relevant literature. This useful manual starts with basic pharmacology and routes of administration, then walks the reader through the effects, adverse-effects and interactions of these drugs in patients with disease in each bodily system. The combination of clinical wisdom and comprehensive reviews of the literature make this book indispensable not only to consultation-liaison psychiatrists but also to any physician interested in the effects on brain and behaviour of the drugs they routinely use.—Michael Sharpe, M.A., M.D., Emeritus Professor of Psychological Medicine University of OxfordPast President, Academy of Consultation-Liaison Psychiatry Current President European Association of Psychosomatic Medicine

As the population ages, it is increasingly common to be prescribing psychotropic medications to patients who are also being treated with other medications for co-occurring medical conditions. Thus, it is important for the practitioner to understand the interface of psychiatric and medical diseases and the effects of psychotropic and nonpsychotropic medications on each other. Consequently, the Clinical Manual of Psychopharmacology in the Medically Ill is a must-have for every psychiatrist's and primary care provider's bookshelf! Now in its Third Edition, the book is conveniently organized by medical illness with comprehensive discussions regarding pharmacokinetics, pharmacodynamics, principles of drug-drug interactions, and severe drug reactions. At the end of each chapter are Key Points that succinctly summarize the important points to remember. The book is a useful tool for the busy practitioner because it synthesizes a large amount of information in an easy-to-read manual with clear explanations.—Anthony J. Rothschild, M.D., Irving S. and Betty Brudnick Endowed Chair and Professor of Psychiatry, University of Massachusetts Chan Medical School, and Editor-in-Chief, Journal of Clinical Psychopharmacology

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