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Windows to the Brain

Insights From Neuroimaging

Robin A. Hurley, M.D., and Katherine H. Taber, PhD, FANPA
Foreword by Stuart C. Yudofsky, M.D., and Robert E. Hales, M.D., M.B.A.

  • ISBN 978-1-58562-302-0
  • Item #62302

Description

Windows to the Brain is the only book to synthesize neuroanatomical and imaging research as it pertains to selected neuropsychiatric diseases, containing all of the “Windows to the Brain” papers published from 1999-2006 in the Journal of Neuropsychiatry and Clinical Neurosciences. These reader-friendly summaries by more than sixty contributors present modern imaging techniques that assist in the diagnosis of neuropsychiatric illness, enhanced by easily understood color graphics of the neuroanatomical circuits of behavior, memory, and emotion. They provide a basic understanding of how to apply a variety of imaging techniques to the study of adult neuropsychiatric disease and how to use neuroimaging to assist in diagnostic work-ups for conditions ranging from sleep disorders to epilepsy to borderline personality.

Integrated, color-coded graphics present functional anatomical information in a manner that promotes understanding and use in clinical practice, while the text encompasses a wide range of diseases and injuries across the adult lifespan. The book is organized into four sections that will help readers increase their appreciation of the wide range of research and clinical applications for imaging in neuropsychiatry: chapters on imaging techniques discuss underlying principles, strengths and weaknesses, and applications; chapters on specific diseases demonstrate a range of investigative techniques; anatomy/circuit chapters focus on particular brain structures or functional neuropsychiatric circuits; and final chapters present image-based approaches to understanding or selecting treatment options. Some of the applications described are:

  • Use of fMRI in posttraumatic stress disorder to reveal the delicate balance between the structures of the emotion and memory tracks;
  • Use of high-resolution MRI and nuclear imaging to distinguish between panic disorder and simple partial seizure disorder;
  • Use of functional imaging studies to detect corticobasal degeneration, as a means of better understanding dementia;
  • Use of newer imaging techniques in identifying progressive multifocal leukoencephalopathy, to enable more rapid and reliable tailoring of individual therapy for HIV;
  • Use of functional neuroimaging in the study of fear, in order to better understand and treat anxiety-based psychiatric disorders;
  • Use of neuroimaging studies in conversion disorder, showing implications for the disruption of selfhood in dissociative identity disorder and schizophrenia;
  • Use of FDG-PET scans to look for predictors of treatment response in childhood-onset obsessive-compulsive disorder.

Windows to the Brain can help bring less-experienced readers up to speed on advanced imaging and anatomical details that pertain to the modern practice of neuropsychiatry. It is must-reading for specialists in neuropsychiatry and cognitive/behavioral neurology, or for general psychiatrists with an interest in neuroimaging.

Contents

CONTRIBUTORS
FOREWORD
PREFACE
Part 1: IMAGING TECHNIQUES
Chapter 1. BLOOD FLOW IMAGING OF THE BRAIN: 50 YEARS’ EXPERIENCE
Chapter 2. FUNCTIONAL MAGNETIC RESONANCE IMAGING: APPLICATION TO POSTTRAUMATIC STRESS DISORDER
Chapter 3. ECSTASY IN THE BRAIN: A MODEL FOR NEUROIMAGING
Chapter 4. THE FUTURE FOR DIFFUSION TENSOR IMAGING IN NEUROPSYCHIATRY
Chapter 5. CORTICAL INHIBITION IN ALCOHOL DEPENDENCE
Chapter 6. APPLICATION OF MAGNETOENCEPHALOGRAPHY TO THE STUDY OF AUTISM
Chapter 7. APPLICATIONS OF XENON COMPUTED TOMOGRAPHY IN CLINICAL PRACTICE: DETECTION OF HIDDEN LESIONS
Chapter 8. NEW TECHNIQUES FOR UNDERSTANDING HUNTINGTON’S DISEASE
Part 2: SPECIFIC DISEASES
Chapter 9. SUDDEN ONSET PANIC: EPILEPTIC AURA OR PANIC DISORDER?
Chapter 10. BIPOLAR DISORDER: IMAGING STATE VERSUS TRAIT
Chapter 11. BLAST-RELATED TRAUMATIC BRAIN INJURY: WHAT IS KNOWN?
Chapter 12. MILD TRAUMATIC BRAIN INJURY: NEUROIMAGING OF SPORTS-RELATED CONCUSSION
Chapter 13. TRAUMATIC AXONAL INJURY: NOVEL INSIGHTS INTO EVOLUTION AND IDENTIFICATION
Chapter 14. FUNCTIONAL IMAGING AS A WINDOW TO DEMENTIA: CORTICOBASAL DEGENERATION
Chapter 15. METACHROMATIC LEUKODYSTROPHY: A MODEL FOR THE STUDY OF PSYCHOSIS
Chapter 16. IDENTIFICATION OF HIV-ASSOCIATED PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY: MAGNETIC RESONANCE IMAGING AND SPECTROSCOPY
Chapter 17. THE EXPANDING ROLE OF IMAGING IN PRION DISEASE
Chapter 18. APPLICATIONS OF FUNCTIONAL IMAGING TO CARBON MONOXIDE POISONING
Chapter 19. BINSWANGER’S DISEASE: AN ONGOING CONTROVERSY
Chapter 20. NORMAL PRESSURE HYDROCEPHALUS: SIGNIFICANCE OF MAGNETIC RESONANCE IMAGING IN A POTENTIALLY TREATABLE DEMENTIA
Chapter 21. NEUROPSYCHIATRIC PRESENTATION OF MULTIPLE SCLEROSIS
Part 3: ANATOMY AND CIRCUITRY
Chapter 22. FUNCTIONAL NEUROANATOMY OF SLEEP AND SLEEP DEPRIVATION
Chapter 23. NEURAL UNDERPINNINGS OF FEAR AND ITS MODULATION: IMPLICATIONS FOR ANXIETY DISORDERS
Chapter 24. RABIES AND THE CEREBELLUM: NEW METHODS FOR TRACING CIRCUITS IN THE BRAIN
Chapter 25. CONVERSION HYSTERIA: LESSONS FROM FUNCTIONAL IMAGING
Chapter 26. THE LIMBIC THALAMUS
Chapter 27. UNDERSTANDING EMOTION REGULATION IN BORDERLINE PERSONALITY DISORDER: CONTRIBUTIONS OF NEUROIMAGING
Chapter 28. FUNCTIONAL ANATOMY OF CENTRAL PAIN
Chapter 29. AN UPDATE ON ESTROGEN: HIGHER COGNITIVE FUNCTION, RECEPTOR MAPPING, NEUROTROPHIC EFFECTS
Part 4: TREATMENT
Chapter 30. PREDICTING TREATMENT RESPONSE IN OBSESSIVE-COMPULSIVE DISORDER
Chapter 31. SCHIZOPHRENIA: WHAT’S UNDER THE MICROSCOPE?
Chapter 32. SURGICAL TREATMENT OF MENTAL ILLNESS: IMPACT OF IMAGING
INDEX

About the Authors

Robin A. Hurley, M.D., is Associate Chief of Staff at the W.G. “Bill” Hefner VAMC in Salisbury, North Carolina, and Associate Professor in the Departments of Psychiatry and Radiology at Wake Forest University School of Medicine, Winston–Salem, North Carolina and Baylor College of Medicine in Houston, Texas.

Katherine H. Taber, Ph.D., is a Research Health Scientist at the W.G. “Bill” Hefner VAMC in Salisbury, North Carolina, and Research Professor in the Division of Biomedical Sciences at the Edward Via Virginia College of Osteopathic Medicine in Blacksburg, Virginia.

Windows to the Brain: Insights From Neuroimaging provides a cutting-edge slice of innovative diagnostic techniques across a diverse range of neuropathology. It both explains the latest in neuroimaging technology and explains the clincial and research application of these techniques. It is certain to become a Go To book as a state-of-the-art reference in the field.—David X. Cifu, M.D., The Herman J. Flax, M.D. Professor and Chairman, Department of Physical Medicine and Rehabilitation, Virginia Commonwealth University School of Medicine


This is an outstanding book, taken from the Windows to the Brain series from the Journal of Neuropsychiatry and Clinical Neurosciences. No neuropsychiatrist should be without a copy.—Doody Enterprises , 4/1/2009

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