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The Neuropsychiatry of Limbic and Subcortical Disorders

Edited by Stephen P. Salloway, M.D., M.S., Paul F. Malloy, Ph.D., and Jeffrey L. Cummings, M.D.

  • ISBN 978-0-88048-942-3
  • Item #8942

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Limbic and subcortical brain regions mediate fundamental functions such as memory, emotion, motivation, and mood. Limbic and subcortical systems also play a key neurobiological role in other important aspects of human experience, such as substance abuse, reward systems, and religious experience. Most neuropsychiatric disorders involve dysfunction of subcortical structures or the limbic or paralimbic cortex. Dysfunction of temporolimbic systems produces some of the most dramatic and challenging syndromes in clinical medicine.

A valuable contribution to the literature on limbic-subcortical systems and neuropsychiatric illness, The Neuropsychiatry of Limbic and Subcortical Disorders presents an overview of functional limbic anatomy and provides a state-of-the-art report on limbic-related syndromes. Part One covers the functional neuroanatomy of limbic and subcortical systems. This emphasis on neuroanatomy provides a foundation for Part Two, which focuses on the limbic system and clinical neuropsychiatric syndromes. Throughout this volume, extensive literature reviews serve as comprehensive reference sources. Many chapters include color illustrations to depict key points. The contributors are a diverse group of leading investigators with special expertise in the functional aspects of limbic and subcortical anatomy and its relationship to neuropsychiatric illness.

The Neuropsychiatry of Limbic and Subcortical Disorders covers a broad range of basic and clinical material at various levels of difficulty. Thus, medical students, psychiatry and neurology residents, psychology trainees, and upper-level undergraduate and graduate students in the basic and clinical neurosciences will find this collection beneficial. Experienced clinicians and researchers in these fields will also benefit from the in-depth material that may even encourage a second read.


  • Introduction to the neuropsychiatry of limbic and subcortical disorders.

    Anatomy and Neurochemistry.

    The limbic system: an anatomic, phylogenetic, and clinical perspective. Ventromedial temporal lobe anatomy, with comments on Alzheimer's disease and temporal injury. The thalamus and neuropsychiatric illness. The accumbens: beyond the core–shell dichotomy. Neurobiology of fear responses: the role of the amygdala.

    Clinical Syndromes.

    Paroxysmal limbic disorders in neuropsychiatry. Auras and experiential responses arising in the temporal lobe. Neuropsychiatric symptoms from the temporolimbic lobes. The neurobiology of emotional experience. The neurobiology of recovered memory. The medial temporal lobe in schizophrenia. Limbic-cortical dysregulation: a proposed model of depression. The neurobiology of drug addiction. The neural substrates of religious experience. Index.

About the Authors

Stephen P. Salloway, M.D., M.S., is Associate Professor of Neurosciences and Psychiatry and Human Behavior at Brown University School of Medicine, and Director of Neurology and the Memory Disorders Program at Butler Hospital in Providence, Rhode Island.

Paul F. Malloy, Ph.D., is Associate Professor of Psychiatry and Human Behavior at Brown University, and Director of Psychology at Butler Hospital in Providence, Rhode Island.

Jeffrey L. Cummings, M.D., is Augustus S. Rose Professor of Neurology and Professor of Psychiatry and Biobehavioral Science at the UCLA School of Medicine in Los Angeles, California.

One of the things I like most about this book is that it attaches importance to both neuroscience and clinical practice. . . . The multiple authorship have indeed acted to ensure that the topics have not been treated in a cursory fashion. The contributors have shown thorough and meticulous scholarship in tracking down available historical material. . . . [T]he book is strongly recommended to anyone dealing with patients having neuropsychiatric disorders or to those with an interest in neurobiology of these disorders.—British Journal of Psychiatry

In the 1950s MacLean postulated that the limbic system mediated emotions; it is most exciting to see flesh and data now clothe this hypothesis. This volume should be read by everyone interested in brain-behavior relationships. Not only is it instructive about the neuroanatomy of the limbic system but it is full of useful clinical descriptions and correlations of structure and function that the clinician will find most practical and useful. This volume is a testament to the progress of the field of neuropsychiatry; it well fulfills the promise of the Decade of the Brain.—Gary J. Tucker, M.D., Professor and Chairman, Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington

The Neuropsychiatry of Limbic and Subcortical Disorders . . . provides an overview of limbic/subcortical neurobiology and its relevance to fundamental functions such as memory, emotion, motivation, and mood, as well as to the clinical syndromes resulting from dysfunction of these brain systems. The contributors to this volume are renowned experts in their respective fields, and they have presented complex material in a very readable format. This book is a 'must read' for anyone interested in the neurobiology of human behavior and experience.—C. Edward Coffey, M.D., Vice President, Henry Ford Behavioral Services, Chairman and Kathleen and Earl Ward Chair of Psychiatry, Henry Ford Health System, Detroit, Michigan

This new volume is highlighted by three important qualities. First, it covers the relevant field of cognitive and psychiatric disorders associated with damaged limbic and subcortical brain regions. Second, the scope of the volume is impressive, from detailed neruoanatomical considerations to broader clinical perspectives such as emotional and even religious experiences. Third, the presentation of information is detailed, scholarly yet readable. It has contributions from top researchers and clinicians in the field of neuropsychiatry and subcortical research. This book will be a very important volume for any clinician and researcher interested in the neuropsychiatry of limbic and subcortical disorders.—Donald T. Stuss, Ph.D., Director, Rotman Research Institute, Professor of Psychology and Medicine (Neurology), University of Toronto, North York, Ontario, Canada

The basal ganglia have been called the crossroads of neurology and psychiatry. If that is true, the limbic system and the paralimbic subcortical structures are the Grand Central Station of neuropsychiatry. This text, based on a special issue of the Journal of Neuropsychiatry and Clinical Neuroscience, strikes the perfect balance between an understanding of brain structure and an appreciation of the clinical disorders associated with limbic dysfunction. The book is authored by some of the world's leading investigators in the anatomy and clinical disorders involving limbic and paralimbic structures. Those who deal with patients having neuropsychiatric disorders or those investigating the substrates of these disorders will find this book an essential resource for their understanding of the clinical anatomical associations which must be appreciated to understand these disorders.—Robert G. Robinson, M.D., The Paul W. Penningroth Professor and Head, College of Medicine, Department of Psychiatry, The University of Iowa, Iowa City, Iowa

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