Skip to content

Melatonin in Psychiatric and Neoplastic Disorders

Edited by Mohammad Shafii, M.D., and Sharon Lee Shafii, R.N., B.S.N.

  • ISBN 978-0-88048-919-5
  • Item #8919

View Pricing

List Price

APA Members

20% off

APA Resident-Fellow Members

25% off

Buying In Canada or Europe?


Provides psychiatrists, oncologists, endocrinologists, pediatricians, and other health professionals with a thorough examination of the most current research on the role of melatonin in psychiatric and neoplastic disorders. This unique textbook and clinical reference is divided into four sections:

  • Evolutionary Development and Neurobiology of the Pineal Gland—discusses the synthesis of melatonin and the anatomy of the pineal gland
  • Melatonin in Psychiatric Disorders in Adults—pioneers in the field of pineology outline their findings on melatonin in the areas of adult depression, sleep disorders, chronobiological mood disorders, bipolar disorders, eating disorders, panic disorders, shift work maladaptation, and jet lag.
  • Melatonin in Children and Adolescents—examines the pineal gland and melatonin in healthy children and adolescents and reviews recent studies on serum and urine melatonin in major depression
  • Melatonin and Neoplastic Disorders—examines melatonin's potential as an antioxidant in cancer cells and its diagnostic and therapeutic value in oncology

The final chapter looks at the role that mindful meditation plays in increasing nocturnal serum melatonin and examines meditation's potential as an adjunct treatment for breast, prostate, and gastrointestinal tract cancers or as a preventive measure for high-risk individuals.

With the expert knowledge and current research presented in Melatonin in Psychiatric and Neoplastic Disorders, clinicians can provide accurate information to their patients on melatonin's role in health and disease.


  • Evolutionary Development and Neurobiology of the Pineal Gland.

    Changes in melatonin throughout the life cycle: implications for neurobiology and psychiatry. The structure and evolutionary development of the pineal gland.

    Melatonin in Psychiatric Disorders in Adults.

    Melatonin in adult depression. Melatonin in circadian phase sleep and mood disorders. Melatonin and circadian rhythms in bipolar mood disorders. Melatonin in eating and panic disorders.

    Melatonin in Children and Adolescents.

    Melatonin in nondepressed and depressed children and adolescents. Melatonin in sleep disorders in children with neurodevelopmental disabilities.

    Melatonin and Neoplastic Disorders.

    Melatonin at the neoplastic cellular level. The melatonin rhythm in cancer patients. Meditation, melatonin, and cancer. Index.

About the Authors

Mohammad Shafii, M.D., is Professor of Psychiatry and Director of the Child and Adolescent Psychiatry Residency Training Program in the Department of Psychiatry and Behavioral Sciences at University of Louisville School of Medicine in Louisville, Kentucky.

Sharon L. Shafii, R.N., B.S.N., is Editor-in-Residence in Louisville, Kentucky. Ms. Shafii was formerly Assistant Head Nurse in the Adolescent Service at the Neuropsychiatric Institute, University of Michigan Medical Center, in Ann Arbor, Michigan.

Psychiatric readers will most benefit from the excellent chapters on the role of circadian rhythms and melatonin production in patient with mood disorders. This is the area—not, as is widely held by the public, in the treatment of primary insomnia—that currently has the strongest theoretical support for a role of melatonin in the pathophysiology and treatment of psychiatric disorders. . . each chapter is superb. . . psychiatric practitioners trying to update themselves on the scientific support for the use of melatonin in psychiatric disorders and for its appropriate use by the public will find this book an informative addition to their library.—American Journal of Psychiatry

This book provides a comprehensive update on this topic and is essential reading for all clinicians.—Doody's Health Sciences Book Review Journal

Melatonin, as noted by Dr. Shafii, has become a 'household' word although much remains unknown concerning the role of this hormone. Melatonin receptor sites are found in many organ systems, not only in the brain. This book, with chapters by leading experts in the field of sleep, reviews not only the current state-of-the-art neurobiology of the pineal gland, but also the potential role of melatonin in psychiatric disorders, sleep disorders, and eating disorders. The most fascinating section addresses the possible role of melatonin in neoplastic disorders. Some of the chapters raise controversial points but there is good documentation of where the field is and why we should pursue further investigations of this molecule. This book is a solid review of where we are in our knowledge and which new areas should be explored.—Dr. Christian Guilleminault, Stanford Health Disorders, Sleep Disorders Clinic, Stanford, California

Related Products

Become an APA Member
Join Now