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Biological Rhythms, Mood Disorders, Light Therapy, and the Pineal Gland

Edited by Mohammad Shafii, M.D., and Sharon Lee Shafii, R.N., B.S.N.

  • ISBN 978-0-88048-169-4
  • Item #8169

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Biological Rhythms, Mood Disorders, Light Therapy, and the Pineal Gland combines the experience of psychiatric clinicians, psychiatric residents, medical students, endocrinologists, psychoimmunologists, neurobiologists, neuroanatomists, and other health professionals to present the most recent progress made in the study of the pineal gland and its relationship to mood disorders, including

  • major depressive disorders
  • winter depression
  • bipolar disorders
  • premenstrual syndrome (PMS)
  • sleep disorders

The use of bright light to treat these disorders is also discussed.


  • Comparative Morphology and Physiology of the Pineal Gland.

    Comparative morphology of the pineal gland. Pineal rhythmicity: neural, behavioral, and endocrine consequences.

    The Pineal Gland and Mood Disorders in Adults, Adolescents, and Children.

    Melatonin as a marker for a subgroup of depression in adults. The pineal gland and depressive disorders in children and adolescents. Melatonin and circadian rhythms in bipolar mood disorders.

    Light Therapy and the Pineal Gland.

    Bright light, melatonin, and winter depression: the phase-shift hypothesis. Melatonin, light therapy, and premenstrual syndrome. Melatonin rhythm disturbances in mood disorders and sleep.

About the Authors

Mohammad Shafii, M.D., is Professor of Psychiatry and Director of the Child and Adolescent Psychiatry Residency Training Program in the Department of Psychiatry and Behavioral Sciences at University of Louisville School of Medicine in Louisville, Kentucky.

Sharon L. Shafii, R.N., B.S.N., is Editor-in-Residence in Louisville, Kentucky. Ms. Shafii was formerly Assistant Head Nurse in the Adolescent Service at the Neuropsychiatric Institute, University of Michigan Medical Center, in Ann Arbor, Michigan.

A superior level of interdisciplinary integration has been achieved in this review of current progress on biological rhythms, mood, light, and the pineal gland. The editors of this volume have chosen appropriate experts to explore the morphology and physiology of the pineal gland, its potential relationship to mood disorders, and the role of melatonin and light therapy in several psychopathological conditions. This volume balances nicely the basic and clinical aspects, and integrates behavioral and treatment components into this emerging dynamic field of biological rhythms.—David J. Kupfer, M.D., Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic

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