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Applied Epigenetics for Mental Health Professionals

Onoriode Edeh, M.D., and Kyle Rutledge, D.O., Ph.D.

  • 2024
  • 192 Pages
  • ISBN 978-1-61537-414-4
  • Item #37414

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Epigenetics—the study of cellular events that affect gene expression without changing the DNA sequence—is having an increasing impact on the field of biology, where it has improved our understanding of the development of pathology and led to novel treatments. The same is true in psychiatry, where epigenetics has provided new perspectives on neurodevelopment across the life span. But although the topic is increasingly present in clinical research (as well as in education, licensing, and board exams), its more complex aspects often exceed the scope of preclinical training.

The essential guide to this growing field of study, Applied Epigenetics for Mental Health Professionals is designed for practicing psychiatrists, psychiatry residents and fellows, nurse practitioners, physician assistants, trainees, and students. Numerous tables and figures, key points that summarize the most pertinent information, and study questions at the end of each chapter are the book's standout features, reinforcing the specific and broadly applicable information throughout.

Opening with an accessible primer to the major concepts that arise in current applications of epigenetics in psychiatry, the book goes on to examine how epigenetics has improved the understanding of

  • Mood disorders, with a focus on depression
  • Neurodevelopmental and neurodegenerative disorders
  • Trauma, toxic stress, and resilience
  • Health-promoting behaviors and aging

Whatever gaps clinicians may have in their knowledge of the core science of epigenetics, Applied Epigenetics for Mental Health Professionals will give them the confidence to incorporate the latest research in the pathology and treatment of psychiatric disorders.


  • Preface
  • Acknowledgments
  • Chapter 1. Overview of Genetic and Epigenetic Mechanisms
  • Chapter 2. Epigenetic Modulation in Major Depressive Disorder
  • Chapter 3. Epigenetics in Neurodevelopmental and Neurodegenerative Disorders

  • Chapter 4. Epigenetics of Childhood Trauma and Resilience
  • Chapter 5. Epigenetics of Lifestyle and Aging
  • Glossary


    Marcelo Branas, M.D.
    Stephen Conway, M.D.
    Marcos Croci, M.D.
    Jeffrey Devido, M.D.
    Carl Fleisher, M.D.
    Robin Gay, Ph.D.
    Robert Gregory, M.D.
    Rocco Iannucci, M.D.
    Julia Jurist, B.A.
    Sam Mermin, B.A.
    Grace Murray, B.A.
    Edward Patzelt, Ph.D.
    Daniel Price, M.D.
    Kim Siscoe, M.D.
    Georgia Steigerwald
    Erik Ydrefelt, Ph.D.

About the Authors

Onoriode Edeh, M.D., is Clinical Assistant Professor of Psychiatry at Central Michigan University College of Medicine, CMU Medical Education Partners, in Saginaw, Michigan.

Kyle J. Rutledge, D.O., Ph.D., graduated from the Psychiatry Residency/Child and Adolescent Psychiatry Fellowship at Central Michigan University College of Medicine, CMU Medical Education Partners, in Saginaw, Michigan, and is working in outpatient clinical practice in Medford, Oregon.

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