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Handbook of Diagnosis and Treatment of Bipolar Disorders

Edited by Terence A. Ketter, M.D.

  • ISBN 978-1-58562-313-6
  • Item #62313

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This readable guide to the assessment and management of patients with bipolar disorder can help physicians keep abreast of dramatic and rapid advances of recent years and integrate them into their practice. Handbook of Diagnosis and Treatment of Bipolar Disorders emphasizes recent controlled studies and FDA-approved indications and translates these data into the real world of clinical practice. The contributions of the eleven chapter authors from Stanford University reflect more than a decade of clinical research and treatment undertaken at that institution, including advances in diagnosis and interventions supported by controlled studies. They provide crucial information regarding diagnosis, pharmacotherapy, psychotherapy, and treatment of patients from special populations—such as children, women, and older adults—and patients with particular challenging illness course such as rapid cycling.

This is the first book to provide quantitative assessment of potential benefit (number needed to treat) and risk (number needed to harm) for all approved treatments for bipolar disorder, providing clinicians with information needed to balance benefits and risks in order to render individualized state-of-the-art, evidence-based care. It describes all FDA-approved indications—reviewing efficacy, safety, tolerability, pharmacokinetics, illness phase-specific dosing, and drug interactions. A chapter on multiphase treatment strategy explains crucial illness transition points and describes how these have been integrated with knowledge of illness phase in mood disorders. The book then demonstrates the relevance of this approach to therapeutics by providing:

  • An overview of pharmacotherapy that covers the emergence of evidence-based pharmacotherapy and number-needed-to-treat and -harm analyses.
  • Guidelines to managing acute manic and mixed episodes that include evidence-based assessments of lithium, divalproex, carbamazepine, and second-generation antipsychotics.
  • Coverage of acute major depressive episodes in bipolar disorders that outlines four tiers of treatment for this most pervasive illness phase with the fewest approved treatments.
  • Discussion of the longer-term management of bipolar disorders, including reviews of controlled trials of recently approved pharmacotherapies such as lamotrigine, olanzapine, aripiprazole, and adjunctive quetiapine.
  • A review of the use of mood stabilizers and second-generation antipsychotics, often in combinations, as well as the controversial role of adjunctive antidepressants in treating patients with rapid-cycling bipolar disorders.
  • Description of important advances in evidence-based adjunctive psychotherapeutic interventions in bipolar depression, and bipolar maintenance treatment.

Comprehensive in scope, yet readily accessible for application to clinical practice, the book includes summary tables, quick-reference lists of clinical pearls, and case studies to make its content more relevant. Handbook of Diagnosis and Treatment of Bipolar Disorders is the ideal source for integrating recent research into everyday practice.


  • Contributors
  • Preface
  • Chapter 1. Principles of Assessment and Treatment of Bipolar Disorders
  • Chapter 2. DSM-IV-TR Diagnosis of Bipolar Disorders
  • Chapter 3. Addressing Clinical Diagnostic Challenges in Bipolar Disorders
  • Chapter 4. Multiphase Treatment Strategy for Bipolar Disorders
  • Chapter 5. Overview of Pharmacotherapy for Bipolar Disorders
  • Chapter 6. Management of Acute Manic and Mixed Episodes in Bipolar Disorders
  • Chapter 7. Management of Acute Major Depressive Episodes in Bipolar Disorders
  • Chapter 8. Longer-Term Management of Bipolar Disorders
  • Chapter 9. Management of Rapid-Cycling Bipolar Disorders
  • Chapter 10. Management of Bipolar Disorders in Children and Adolescents
  • Chapter 11. Management of Bipolar Disorders in Women
  • Chapter 12. Management of Bipolar Disorders in Older Adults
  • Chapter 13. Mood Stabilizers and Antipsychotics: Pharmacokinetics, Drug Interactions, Adverse Effects, and Administration
  • Chapter 14. Antidepressants, Anxiolytics/Hypnotics, and Other Medications: Pharmacokinetics, Drug Interactions, Adverse Effects, and Administration
  • Chapter 15. Adjunctive Psychosocial Interventions in the Management of Bipolar Disorders
  • Appendices:
  • A. Florida Best Practice Medication Guidelines for Bipolar Disorder
  • B. Quick Reference Medication Facts
  • C. Quick Reference Resources and Readings
  • Index


    John O. Brooks III, Ph.D., M.D.
    Kiki D. Chang, M.D.
    Jenifer L. Culver, Ph.D.
    Meghan Howe, M.S.W.
    Terence A. Ketter, M.D.
    Laura C. Pratchett, M.S.
    Natalie L. Rasgon, M.D., Ph.D.
    Manpreet K. Singh, M.D., M.S.
    Barbara R. Sommer, M.D.
    Po W. Wang, M.D.
    Laurel N. Zappert, Psy.D.

About the Authors

Terence A. Ketter, M.D., is Professor of Psychiatry and Behavioral Sciences in the Department of Psychiatry and Behavioral Sciences, and Chief of the Bipolar Disorders Clinic at Stanford University School of Medicine in Stanford, California.

Dr. Ketter and his colleagues have provided for us a timely clinical guide for one of our most disabling disorders, namely bipolar disorder. A wonderful mix of evidence-based and clinical expertise, this clinical manual sets a new standard for assessment and management manuals for psychiatric disorders. Since the field is rapidly advancing, I will look forward already to the next edition.—David J. Kupfer, M.D., Professor and Chair, Department of Psychiatry, University of Pittsburgh School of Medicine

This is a treasure trove of information and guidance for anyone who treats individuals with bipolar disorder or who wants to learn to do so. The authors succeed in their goal of attempting to provide clinicians with the empirical data needed to balance benefit and risk. I'd like to have two copies of this valuable collection of chapters: one for the office as a guide to treatment and one for home as a reference to the rapidly growing literature on the treatment of bipolar disorder.—Ellen Frank, Ph.D., Distinguished Professor of Psychiatry, University of Pittsburgh School of Medicine

Treatment of bipolar disorders is both complex and rapidly changing. Management strategies often reflect a mix of clinical experience and evidence-based literature. This manual comprehensively distills the vast amount of literature examining the efficacy, safety, tolerability, pharmacokinetics, illness phase-specific dosing, and drug interactions of medications used to treat the various aspects of bipolar illness. It presents the information in a clinically relevant, wonderfully organized manner. I highly recommend this to any practitioner who provides care for individuals with bipolar illness.—Heather Huang, M.D., Doody Enterprises, 1/1/2010

This handbook is a true tour de force for clinicians who want to acquire and/or improve their skills in the diagnosis and management of patients with bipolar disorder.—Robert M. A. Hirschfeld, M.D., The Journal of Clinical Psychiatry, 1/1/2010

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