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The American Psychiatric Publishing Textbook of Alzheimer Disease and Other Dementias

Edited by Myron F. Weiner, M.D., and Anne M. Lipton, M.D., Ph.D.

  • ISBN 978-1-58562-278-8
  • Item #62278

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The American Psychiatric Publishing Textbook of Alzheimer Disease and Other Dementias is an up-to-date and comprehensive overview of dementia for psychiatrists and other health care practitioners who deal with cognitively impaired adults in outpatient, inpatient, and long-term care settings. With content ranging from clinical guidance to basic research, it contains information on nearly every subject related to dementing conditions or illnesses—not only providing extensive coverage of clinical management issues but also enabling a deeper understanding of the causes of dementia. Designed to assist the practitioner faced with everyday dilemmas, from dosages of antipsychotic drugs to legal and ethical issues, this textbook describes in detail the most common conditions and diseases leading to dementia and covers pharmacologic, behavioral, and environmental treatments. It also considers a broader range of cognitive disorders and impairment in order to help practitioners recognize and treat primary brain diseases and systemic disorders affecting the brain before they reach the stage of dementia.

Building on the editors' earlier work The Dementias: Diagnosis, Treatment, and Research, this new book expands on its scope, with nearly twice the number of contributors—all clinicians or researchers at the vanguard of the field. New to this edition are chapters on epidemiology, history of dementia, biomarkers for Alzheimer disease, care of the late-stage dementia patient, prevention of dementia, and chapters devoted to:

  • Vascular cognitive impairment, emphasizing the importance of early detection with development of appropriate treatments and risk factor control
  • Dementia with Lewy bodies and other synucleinopathies, describing differences in cognitive profile between synucleinopathies and Alzheimer disease
  • Frontotemporal dementias, including behavioral and language variants
  • Traumatic brain injury, distinguishing between proximal and distal effects and risk factors for dementia later in life

An abundance of charts and illustrations, extensive references and additional readings, and chapter-end key points make this a practical volume for learning, while appendixes include easily administered instruments useful in daily practice for grading cognition, day-to-day function, neuropsychiatric symptoms, and quality of life. Whether used as a clinical guide or as a sourcebook on technical and scientific developments, The American Psychiatric Publishing Textbook of Alzheimer Disease and Other Dementias is an important reference for psychiatrists, neurologists, geriatricians, primary care physicians, and other health professionals who deal with cognitively impaired adults.


  • Contributors
  • Foreword
  • Preface
  • PART I: Introduction to the Dementias
  • Chapter 1. Dementia and Alzheimer Disease: Ancient Greek Medicine to Modern Molecular Biology
  • Chapter 2. Epidemiology and Impact of Dementia
  • PART II: Evaluation and Diagnosis of Dementia
  • Chapter 3. Neuropsychiatric Assessment and Diagnosis
  • Chapter 4. Medical Evaluation and Diagnosis
  • Chapter 5. Neuropsychological Assessment in Dementia
  • Chapter 6. Neuroimaging
  • Chapter 7. Cognitive Disorders as Psychobiological Processes
  • PART III: Alzheimer Disease and Other Dementias
  • Chapter 8. Alzheimer Disease
  • Chapter 9. Mild Cognitive Impairment
  • Chapter 10. Vascular Cognitive Disorder
  • Chapter 11. Dementia With Lewy Bodies and Other Synucleinopathies
  • Chapter 12. Frontotemporal Dementia
  • Chapter 13. Traumatic Brain Injury
  • Chapter 14. Other Causes of Dementia
  • Chapter 15. Psychiatric Disorders in People With Dementia
  • PART IV: Treatment of Dementia
  • Chapter 16. Pharmacological Treatment of Neuropsychiatric Symptoms
  • Chapter 17. Behavioral and Environmental Management
  • Chapter 18. Pharmacological Treatment of Alzheimer Disease and Mild Cognitive Impairment
  • Chapter 19. Management of Advanced Dementia
  • PART V: Caregiving, Legal, and Ethical Issues
  • Chapter 20. Supporting Family Caregivers
  • Chapter 21. Legal Issues
  • Chapter 22. Ethical Issues and Patterns of Practice
  • PART VI: Dementias: The Future
  • Chapter 23. Biomarkers for the Dementias
  • Chapter 24. The Molecular and Genetic Basis of Alzheimer Disease
  • Chapter 25. The Future of Dementia Treatment
  • Chapter 26. Prevention of Dementia and Cognitive Decline
  • Index


    Marilyn S. Albert, Ph.D.
    Rebecca S. Allen, Ph.D.
    David Ames, B.A., M.D., F.R.C.Psych., F.R.A.N.Z.C.P.
    J. Wesson Ashford, M.D., Ph.D.
    Erin D. Bigler, Ph.D.
    Malaz Boustani, M.D., M.P.H.
    Adam Boxer, M.D., Ph.D.
    Carol Brayne, M.Sc., M.D.
    John C.S. Breitner, M.D., M.P.H.
    Mary E. Bret, M.D.
    Katharina Burger, M.D.
    Louis D. Burgio, Ph.D.
    Stephen Campbell, F.R.A.C.P., M.Ch.B.S., B.Sc.
    Danielle China, M.S.
    Edmond Chiu, A.M., M.B.B.S., D.P.M., F.R.A.N.Z.C.P.
    C. Munro Cullum, Ph.D., A.B.P.P.
    Martin R. Farlow, M.D.
    Norman L. Foster, M.D.
    Lawrence A. Frolik, J.D., L.L.M.
    Dolores Gallagher-Thompson, Ph.D., A.B.P.P.
    James E. Galvin, M.D., M.P.H.
    Robert Garrett, M.D.
    Yonas E. Geda, M.D., M.Sc.
    David S. Geldmacher, M.D.
    Harald-Jurgen Hampel, M.D., M.Sc.
    Michelle M. Hilgeman, M.A.
    Jason Holland, M.S.
    Julian C. Hughes, M.A., M.B., Ch.B., M.R.C.Psych., Ph.D.
    Laura H. Lacritz, Ph.D., A.B.P.P.
    Anne M. Lipton, M.D., Ph.D.
    Katy H. Lonergan, M.S.
    Constantine G. Lyketsos, M.D., M.H.S.
    Selamawit Negash, Ph.D.
    Ronald C. Petersen, Ph.D., M.D.
    Mary Quiceno, M.D.
    Danielle Richards
    Roger N. Rosenberg, M.D.
    Craig D. Rubin, M.D.
    Mary Sano, Ph.D.
    George M. Savva, Ph.D.
    Joyce Simard, M.S.W.
    Martin Steinberg, M.D.
    Cassandra E.I. Szoeke, Ph.D., F.R.A.C.P., M.B.B.S., B.Sc. (Hons)
    Pierre N. Tariot, M.D.
    Rawan Tarawneh, M.D.
    Ladislav Volicer, M.D., Ph.D., F.A.A.N., F.G.S.A.
    Myron F. Weiner, M.D.
    Roy Yaari, M.D.
    Edward Zamrini, M.D.

About the Authors

Myron F. Weiner, M.D., is Clinical Professor of Psychiatry and Neurology; Aradine S. Ard Chair in Brain Science; and Dorothy L. and John P. Harbin Chair in Alzheimer's Disease Research, University of Texas Southwestern Medical Center in Dallas, Texas.

Anne M. Lipton, M.D., Ph.D., is in the Department of Neurology at Presbyterian Hospital of Dallas in Dallas, Texas.

This book masterfully achieves its stated goal of one-stop-shopping for clinicians interested in updating their knowledge about cognitive disorders. The editors have succeeded in combining clinically pragmatic didactics with state-of-the-art science in chapters that are well written, understandable, and just the right length.—Eugene H. Rubin, M.D., Ph.D., Professor of Psychiatry and Vice-Chair for Education, Clinical Investigator, Alzheimer's Disease Research Center, Washington University in St Louis – School of Medicine

As the proportion of older people in the population continues to increase, Alzheimer disease and related dementias will afflict a growing number of patients and their families. This authoritative text is an important reference for professionals involved in dementia research and care. Dr. Myron Weiner has done a superb job in editing a work that brings together internationally recognized experts who span a range of relevant topics, from epidemiology to neuroimaging. Up-to-date, clear, and comprehensive, The American Psychiatric Publishing Textbook of Alzheimer Disease and Other Dementias will become the essential volume for scientists, clinicians, and professional students.—Gary W. Small, M.D., Parlow-Solomon Prof on Aging, Prof of Psychiatry & Biobehavioral Sci, Director, UCLA Ctr on Aging, Director, Memory & Aging Research Ctr, Semel Inst Neuroscience & Human Behavior

Busy practitioners will be pleasantly surprised at the timeliness and utility of the The American Psychiatric Publishing Textbook of Alzheimer Disease and Other Dementias. This multi-authored text anticipates the avalanche of new information on diagnosis and treatment of the dementias as well as the medical-legal, long-term care, and end-of-life issues that will increasingly emerge as the active life span of persons with dementia is extended. Pharmacologic, behavioral, and caregiver issues receive extensive coverage as do the vexing problems of traumatic brain injury and mild cognitive impairment. From the first descriptions of dementia in antiquity to preventive interventions currently beyond the horizon, Drs. Weiner and Lipton prepare readers to provide good care today and better care tomorrow. The comprehensive historical perspective gives the reader an informed perspective from which to view new developments in dementia science with both caution and optimism. The American Psychiatric Publishing Textbook of Alzheimer Disease and Other Dementias describes the state of the science as well as the clinical practices necessary to provide comprehensive care and a forward looking stance for dementia patients and their families. No textbook on a disease which is the focus of so immense a research effort can hope to be to up to date at the time of publication. However Drs. Weiner and Lipton offer far reaching coverage of the topic which prepares clinicians to make informed assessments of emerging developments in the area of dementia. As a result, this text will have an unusually long shelf life. The authors offer guidance through the maze of diagnostic procedures, medications, and psychosocial interventions. This is an essential resource for any health care professional hoping to improve the care of persons with dementia. Health care providers will benefit from this work. And so will their patients.—Gary J. Kennedy, M.D., Director, Division of Geriatric Psychiatry, Department of Psychiatry, Montefiore Medical Center

This is a marvelous new and comprehensive textbook covering the dementias and related cognitive disorders. Everything a clinician would want to know about these difficult disorders is contained in this excellent textbook.—Doody Enterprises, 2/1/2010

The text is an important resource for psychiatrists and other mental health professionals, whether they are reading it from cover to cover or using it as a reference.—Joseph Tonkonogy, M.D., Ph.D., Psychiatric Services, 2/1/2010

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