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The Evidence-Based Guide to Antidepressant Medications

Edited by Anthony J. Rothschild, M.D.

  • ISBN 978-1-58562-980-0
  • Item #62980

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The second book in the Evidence-Based Guides series, The Evidence-Based Guide to Antidepressant Medications, provides a clear reference to the current knowledge and evidence base for the use of antidepressants among a variety of patients across a wide range of disorders. Chapters within this guide are authored by experts in their respective areas of practice, and synthesize a large amount of medical literature into a comprehensive, yet understandable, concise, reader-friendly guide. Each chapter covers both the FDA-approved and off-label use of antidepressant medications and the evidence base for their use. Each chapter also features useful tables pertaining to specific topics, such as summaries of uses and efficacy, and important clinical pearls of wisdom in the Key Clinical Concepts. Topics covered in chapters within this text include:

  • Use of selective serotonin reuptake inhibitors, MAOIs, and tricyclic antidepressants in major depressive disorder, bipolar depression, psychotic depression, and treatment-resistant depression.
  • Acute management of anxiety disorders, obsessive-compulsive disorder, and specific phobias through antidepressant use.
  • Use of antidepressant medication in medically ill patients, such as those with cardiovascular, pulmonary, gastrointestinal, renal, and endocrine diseases, as well as cancer, chronic pain, HIV, burns and hospital-based trauma.
  • Developmental considerations necessary to keep in mind when prescribing antidepressants to children and adolescents, along with an outline of controlled studies and their special attention to safety.
  • Medication management in geriatric patients, including antidepressant use among depressed elderly patients with dementia, stroke, or Parkinson's disease.
  • Risks and benefits of prescribing antidepressants during pregnancy and lactation.

Together, the authors have synthesized a large amount of medical literature into a comprehensive, yet understandable, concise, reader-friendly guide. The Evidence-Based Guide to Antidepressant Medications is a must-have reference for psychiatrists and other practicing clinicians, residents in training, psychiatric nurses, social workers and researchers.


  • Contributors
  • Acknowledgments
  • Disclaimer
  • Chapter 1. Introduction
  • Chapter 2. Unipolar and Bipolar Depression
  • Chapter 3. Anxiety Disorders
  • Chapter 4. Schizophrenia and Schizoaffective Disorder
  • Chapter 5. Personality Disorders
  • Chapter 6. Substance-Related Disorders
  • Chapter 7. Use of Antidepressants in Children and Adolescents
  • Chapter 8. Use of Antidepressants in Geriatric Patients
  • Chapter 9. Use of Antidepressants in Medically Ill Patients
  • Chapter 10. Use of Antidepressants During Pregnancy and Lactation
  • Chapter 11. Use of Antidepressants in Patients Receiving Nursing Care
  • Index


    Mary S. Ahn, M.D.
    Nancy Byatt, D.O., M.B.A.
    Kristina M. Deligiannidis, M.D.
    Deepak Cyril D'Souza, M.D.
    Jean A. Frazier, M.D.
    Stacey B. Gramann, D.O., M.P.H.
    Cassandra Hobgood, M.D.
    Michael D. Jibson, M.D., Ph.D.
    Ryan J. Kimmel, M.D.
    Benjamin Liptzin, M.D.
    Avram H. Mack, M.D., F.A.P.A.
    Rajiv Radhakrishnan, M.D.
    Anthony J. Rothschild, M.D.
    Peter P. Roy-Byrne, M.D.
    Judith Shindul-Rothschild, Ph.D., R.N.P.C.
    Kenneth R. Silk, M.D.
    Lauren Yakutis, B.A.

About the Authors

Anthony J. Rothschild, M.D., is Irving S. and Betty Brudnick Endowed Chair and Professor of Psychiatry at the University of Massachusetts Medical School and UMass Memorial Healthcare in Worcester, Massachusetts.

This up-to-date guide is just what Advanced Practice Psychiatric Nurses need to provide quality care to patients who are prescribed antidepressant s. Each chapter is chock full of study results, myth busters, and critical information for prescribing. No desk top should be without it!—Margaret Knight Ph.D., PMHCNS-BC, Assistant Professor, University of Massachusetts Lowell

Rothschild and his collaborators have produced a wonderful, comprehensive guide to a class of medications that have become ubiquitous in modern psychiatric practice. It offers sophisticated approaches to the use of antidepressants for a broad range of disorders, providing the information that both clinicians and patients need to make optimal treatment choices. My copy is sure to be one of the best-thumbed reference books on my shelves.—Paul S. Appelbaum, M.D., Dollard Professor of Psychiatry, Medicine, and Law Columbia University

The Evidence-Based Guide to Antidepressant Medications contains outstanding work conducted by leading authorities in mood disorders. This guide provides a thorough review of the literature on what is known about antidepressants across psychiatric disorders, over the life span and in special populations. There are practical tables, figures, tips, recommendations, and references to help guide the clinician in the management of their patients. This book is very suitable for a wide audience ranging from medical students, residents, fellows, and clinical health professions.—Carlos A. Zarate, Jr., M.D., Chief Experimental Therapeutics & Pathophysiology Branch, Division Intramural Research Programs, National Institute of Mental Health, Bethesda, Maryland

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