Skip to content

DSM-5-TR® Handbook of Differential Diagnosis

Michael B. First, M.D.

  • 2024
  • 388 Pages
  • ISBN 978-1-61537-360-4
  • Item #37360

View Pricing

List Price

APA Members

20% off

APA Resident-Fellow Members

25% off


The DSM-5-TR Handbook of Differential Diagnosis is the preeminent guide to differential diagnosis for both clinicians and students learning psychiatric diagnosis. Fully updated to reflect the recent Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR), this handbook includes two newly developed diagnostic trees (for dissociative symptoms and repetitive pathological behaviors). This indispensable guide offers a rich selection of diagnostic lenses through which to consider symptomatic presentations, grounded in the latest research and standards of practice.

Written by the DSM-5-TR Editor, an expert on psychiatric diagnosis and assessment, the handbook guides clinicians and students on how to differentiate between disorders with similar presentations in an accessible, easy-to-use format. An assortment of approaches to differential diagnosis and a number of features designed to benefit the evaluation include:

  • A six-step framework for diagnosing patients that proceeds from determining if the presenting symptoms are due to a substance/medication or a medical condition, to establishing the boundary between disorder and normality, to determining the primary disorder, and differentiating adjustment disorders from other mental disorders.
  • Thirty symptom-oriented decision trees, two of which are new to this edition, that provide detailed decision points to facilitate the process of generating the differential diagnosis based on the presenting symptoms and eliminate formulating premature conclusions.
  • Sixty-seven differential diagnosis tables, one for each of the most important disorders in DSM-5-TR, cross-referenced with the terminal branches of the decision trees presented in the handbook and that provide a head-to-head comparison of each disorder, highlighting similarities and differences.
  • The DSM-5-TR Classification, to facilitate coding and to provide an overview of all the DSM-5-TR diagnoses that must be considered in formulating a differential diagnosis.

DSM-5-TR Handbook of Differential Diagnosis provides a comprehensive overview of the process of diagnosing DSM-5-TR disorders while serving as a reference guide to assist in the differential diagnosis of individual patients. Clinicians and students learning psychiatric diagnosis faced with this most crucial task will find this handbook of enormous benefit.


  • Preface
  • Chapter 1. Differential Diagnosis Step by Step
  • Chapter 2. Differential Diagnosis by the Trees
  • Chapter 3. Differential Diagnosis by the Tables
  • Appendix: DSM-5-TR Classification
  • Alphabetical Index of Decision Trees
  • Alphabetical Index of Differential Diagnosis Tables

About the Authors

Michael B. First, M.D., is Professor of Clinical Psychiatry at Columbia University in New York, New York.

Related Products

Become an APA Member
Join Now