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Biology of Anxiety Disorders

Edited by Rudolf Hoehn-Saric, M.D., and Daniel R. McLeod, Ph.D.

  • ISBN 978-0-88048-476-3
  • Item #8476

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Under normal circumstances, anxiety is a biological warning system that enables a person to anticipate and avoid harm and failure. Recent advances in the physiology and pharmacology of the central nervous system, and technical advances (imaging in particular), have opened new avenues toward a better understanding of the biology of anxiety.

Written by a renowned group of experts, Biology of Anxiety Disorders provides the most recent data on the neurobiology and pathophysiology of anxiety from a variety of perspectives. The book discusses recent advances in neuroimaging that have enhanced the study of anxiety such as measurement of cerebral blood flow and metabolic rate. The authors discuss the biology of serotonin receptors and relate these findings to a variety of anxiety disorders. The book reviews several kindling models and how they can be used to shed light on mechanisms, such as the induction of proto-oncogenes, that affect responsivity to panic-inducing stimuli. Biology of Anxiety Disorders also covers the peripheral physiological manifestations of anxiety, including recent findings on the physiological expression of anxiety disorders, and explores the relationship between these objective bodily changes and the subjective perception of these changes.


  • Cerebral blood flow and metabolism in anxiety disorders. Serotonin in the pathogenesis of anxiety. The role of corticotropin-releasing factor in the pathophysiology of anxiety disorders. Implications of cocaine kindling, induction of the proto-cogene c-fos and contingent tolerance in panic disorder. Somatic manifestations of normal and pathological anxiety. Perception of physiological changes in normal and pathological anxiety. Concluding remarks. Index.

About the Authors

Rudolf Hoehn-Saric, M.D., is a Professor of Psychiatry at Johns Hopkins School of Medicine in Baltimore, Maryland.

Daniel R. McLeod, Ph.D., is an Assistant Professor of Psychiatry at Johns Hopkins School of Medicine in Baltimore, Maryland.

The seven contributions summarize a wealth of current research on cerebral blood flow, serotonin, and corticotropin-releasing factor, including somatic manifestations and perception of physiological changes.—Bulletin of the Menninger Clinic

This volume provides excellent summaries of several recent areas of inquiry in the basic science of anxiety disorders.—Hospital and Community Psychiatry

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