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The American Psychiatric Association Publishing Textbook of Anxiety, Trauma, and OCD-Related Disorders, Third Edition

Edited by Naomi Simon, M.D., MSc, Eric Hollander, M.D., Barbara O. Rothbaum, Ph.D., A.B.P.P., and Dan J. Stein, M.D., Ph.D.

  • ISBN 978-1-61537-292-8
  • Item #37292

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Designed for clinicians at every level, The American Psychiatric Association Publishing Textbook of Anxiety, Trauma, and OCD-Related Disorders addresses the origin, assessment, diagnosis, and treatment of these disorders in a comprehensive, up-to-date, and compelling manner. Fresh voices are everywhere in this authoritative revision of the classic text, as more than 60% of the contributors are new. They join stalwarts from the previous edition—experts who bring stellar credentials and a discerning eye to the task of revising the text to reflect cutting-edge scholarship and evidence-based clinical knowledge. Following a comprehensive overview of core principles, the book provides detailed coverage of specific DSM-5 diagnoses: generalized anxiety disorder, obsessive-compulsive and related disorders, panic disorder and agoraphobia, social anxiety disorder, specific phobia, and trauma- and stressor-related disorders. Each section presents the latest thinking on phenomenology and pathogenesis, then provides evidence-based clinical recommendations for pharmacotherapy and psychotherapy.

New and noteworthy material includes the following:

  • Two new chapters focus on the features, phenomenology, and course of acute and integrated grief, as well as the epidemiology, clinical features, evaluation, and pathophysiology of complicated grief (CG), which affects a significant minority. Proper treatment of CG is critical, because once it persists beyond 6 months, impairment may last for years, if not a lifetime. Accordingly, a separate chapter is devoted to treatment options, including a hybrid of cognitive-behavioral, interpersonal, motivational interviewing, and psychodynamic methods.
  • The Unified Protocol (UP) for Transdiagnostic Treatment of Emotional Disorders is examined in a fascinating new chapter. The UP is a promising treatment with empirical support for reduction of both symptoms and higher-order temperamental changes, such as changes in neuroticism, an underlying mechanism associated with onset and maintenance of emotional disorders.
  • The chapter on anxiety disorders in late life is completely new and emphasizes the prevalence of anxiety in this population and its likelihood of remaining undetected and untreated. The epidemiology, diagnosis, and treatment of these disorders are examined in detail so that the reader will recognize the clinical features, be able to differentiate them from depression, and can identify appropriate treatment, whether pharmacological or psychotherapeutic.
  • Each chapter features a concise list of key clinical points to help the reader focus on the most important material for study, as well as a list of recommended reading for those who wish to learn more.

Grounded in the latest research, clinically rich, and pedagogically strong, The American Psychiatric Association Publishing Textbook of Anxiety, Trauma, and OCD-Related Disorders is the go-to text for mental health clinicians looking for evidence-based knowledge and support.


  • Part 1. Approaching Anxiety Disorders

  • Chapter 1. Anxiety and Related Disorders
  • Chapter 2. Genetic Contributions to Anxiety Disorders
  • Chapter 3. Neural Circuits in Fear and Anxiety
  • Chapter 4. Cultural and Social Aspects
  • Chapter 5. Economic and Social Burden
  • Part 2. Core Principles for Treating Anxiety Disorders

  • Chapter 6. Cognitive-Behavioral Concepts
  • Chapter 7. Psychodynamic Concepts and Treatment
  • Chapter 8. Unified Protocol
  • Chapter 9. Combined Treatment
  • Chapter 10. Core Principles in Pharmacotherapy
  • Part 3. Generalized Anxiety Disorder

  • Chapter 11. Phenomenology of GAD
  • Chapter 12. Pathogenesis of GAD
  • Chapter 13. Pharmacotherapy for GAD
  • Chapter 14. Psychotherapy for GAD
  • Part 4. Obsessive-Compulsive Disorder/Related Disorders

  • Chapter 15. Phenomenology of OCD
  • Chapter 16. Pathophysiology of OCDs
  • Chapter 17. Pharmacotherapy for OCD
  • Chapter 18. Psychological Treatment for OCD
  • Chapter 19. Obsessive-Compulsive Spectrum
  • Part 5. Panic Disorder and Agoraphobia

  • Chapter 20. Phenomenology of Panic
  • Chapter 21. Pathogenesis of Panic
  • Chapter 22. Pharmacotherapy for Panic
  • Chapter 23. Psychotherapy for Panic
  • Part 6. Social Anxiety Disorder (Social Phobia)

  • Chapter 24. Phenomenology of Social Anxiety
  • Chapter 25. Pathogenesis of Social Anxiety
  • Chapter 26. Pharmacotherapy for Social Anxiety
  • Chapter 27. Psychotherapy for Social Anxiety
  • Part 7. Specific Phobia

  • Chapter 28. Specific Phobia
  • Part 8. Trauma- and Stressor-Related Disorders

  • Chapter 29. Phenomenology of PTSD
  • Chapter 30. Pathogenesis of PTSD and Acute Stress Disorder
  • Chapter 31. Pharmacotherapy for PTSD
  • Chapter 32. Psychotherapy for PTSD
  • Chapter 33. Phenomenology of Persistent Grief
  • Chapter 34. Treatment of Persistent Grief
  • Part 9. Anxiety Disorders and Comorbidity

  • Chapter 35. Mixed Anxiety-Depressive Disorder
  • Chapter 36. Anxiety in Substance Use Disorders
  • Chapter 37. Anxiety Disorders in Medical Settings
  • Chapter 38. Anxiety and Insomnia
  • Part 10. Anxiety Disorders in Special Populations

  • Chapter 39. Childhood Anxiety
  • Chapter 40. Anxiety in Late Life
  • Index


    Jonathan S. Abramowitz, Ph.D.
    Anne Marie Albano, Ph.D., ABPP
    Andrea R. Ashbaugh, Ph.D.
    Sudie E. Back, Ph.D.
    Amanda Waters Baker, Ph.D.
    David S. Baldwin, M.A., D.M., FRCPsych
    Borwin Bandelow, M.D., Ph.D.
    David H. Barlow, Ph.D., ABPP
    Abigail L. Barthel, M.A.
    Janna Marie Bas-Hoogendam, M.Sc.
    Katja Beesdo-Baum, Ph.D.
    Colleen Gribbin Bloom, M.S.W.
    Christina L. Boisseau, Ph.D.
    Kathleen T. Brady, M.D., Ph.D.
    J. Douglas Bremner, M.D.
    Lily A. Brown, Ph.D.
    Richard A. Bryant, Ph.D.
    Jennifer L. Buchholz, M.A.
    Elisabetta Burchi, M.D.
    Mark Burton, Ph.D.
    Fredric N. Busch, M.D.
    Rebecca P. Cameron, Ph.D.
    Craig Campbell, M.D.
    Denise April Chavira, Ph.D.
    Eduardo Cinosi, M.B.B.S., MRCPsych
    Jeremy D. Coplan, M.D.
    Bernadette M. Cortese, Ph.D.
    Stephen J. Cozza, M.D.
    Kevin J. Craig, M.B.B.Ch., M.Phil., MRCPsych
    Michelle G. Craske, Ph.D.
    Andrew J. Curreri, M.A.
    Grishma Dabas, B.Sc.
    Jonathan R.T. Davidson, M.D.
    Jurgen Deckert, M.D.
    Michael Diamond, M.D.
    Darin D. Dougherty, M.D.
    Boadie W. Dunlop, M.D.
    Jane L. Eisen, M.D.
    Thalia C. Eley, Ph.D.
    Todd J. Farchione, Ph.D.
    Jan Fawcett, M.D.
    Naomi A. Fineberg, M.B.B.S., M.A., MRCPsych
    Edna B. Foa, Ph.D.
    Andrew W. Goddard, M.D.
    Benedetta Grancini, M.D.
    Benjamin D. Greenberg, M.D., Ph.D.
    Richard G. Heimberg, Ph.D.
    Gert-Jan Hendriks, Ph.D., M.D.
    John M. Hettema, M.D., Ph.D.
    Stefan G. Hofmann, Ph.D.
    Elizabeth Hoge, M.D.
    Eric Hollander, M.D.
    Arielle Horenstein, M.A.
    Jonathan D. Huppert, Ph.D.
    Simona C. Kaplan, M.A.
    Cary S. Kogan, Ph.D.
    Karen Kraus, M.D.
    Barry Lebowitz, Ph.D.
    Roberto Lewis-Fernandez, M.D.
    Betty Liao, Ph.D.
    Jessica L. Maples-Keller, Ph.D.
    Zoya Marinova, M.D., Ph.D.
    Daniel Marrello, B.Sc.
    Alexander C. McFarlane, M.D.
    Sandra Meier, Ph.D.
    Emily Mellen, B.A.
    Julia Merker, B.S.
    Barbara L. Milrod, M.D.
    Charles B. Nemeroff, M.D., Ph.D.
    Ella L. Oar, Ph.D.
    Miranda Olff, Ph.D.
    Michael W. Otto, Ph.D.
    Beth Patterson, B.Sc.N., B.Ed., M.Sc.
    Sandra S. Pimentel, Ph.D.
    Mark H. Pollack, M.D.
    Carolyn Ponting, M.A.
    Brianna Prichett, B.S.
    Ronald M. Rapee, Ph.D.
    Steven A. Rasmussen, M.D.
    Scott L. Rauch, M.D.
    Jemma Reid, M.B.B.S., MRCPsych
    Kerry J. Ressler, M.D., Ph.D.
    Charles Reynolds, M.D.
    Eline F. Roelofs, M.D.
    Valerie Rosen, M.D.
    Barbara O. Rothbaum, Ph.D.
    William C. Sanderson, Ph.D.
    Alan F. Schatzberg, M.D.
    Franklin R. Schneier, M.D.
    Josien Schuurmans, Ph.D.
    Erin Shanahan, B.S.
    Isobel Sharpe, B.Sc.
    M. Katherine Shear, M.D.
    Ayotunde Shodunke, M.B.B.S., M.Sc., MRCPsych
    Nicole A. Short, Ph.D.
    Naomi M. Simon, M.D., M.Sc.
    Natalia Skritskaya, Ph.D.
    Jordan W. Smoller, M.D., Sc.D.
    Carolyn Spiro-Levitt, Ph.D.
    Stephanie Jarvi Steele, Ph.D.
    Simona Stefan, Ph.D.
    Dan J. Stein, M.D.
    Murray B. Stein M.D., M.P.H.
    Amina Sutherland-Stolting, M.D.
    Michaela B. Swee, M.A.
    Ilanit R. Tal, Ph.D.
    Alexandra S. Tanner, M.A.
    Charles T. Taylor, Ph.D.
    David F. Tolin, Ph.D.
    Antolin Trinidad, M.D., Ph.D.
    Thomas W. Uhde, M.D.
    Michael Van Ameringen, M.D., FRCPC
    Nic J.A. van der Wee, M.D., Ph.D.
    Claire Van Genugten, M.Sc.
    Richard Oude Voshaar, Ph.D., M.D.
    Rushi H. Vyas, M.D.
    Mengxing Wang, M.A.
    Ryan D. Webler, B.A.
    P. Michiel Westenberg, Ph.D.
    Monnica T. Williams, Ph.D.
    Thomas N. Wise, M.D.
    Brittany K. Woods, M.A.
    Sidney Zisook, M.D.

About the Authors

Naomi M. Simon, M.D., M.Sc., is Professor of Psychiatry at New York University School of Medicine and Director of the Anxiety and Complicated Grief Program in the Department of Psychiatry at NYU Langone Health in New York, New York.

Eric Hollander, M.D., is Professor of Psychiatry and Behavioral Sciences at the Albert Einstein College of Medicine and Director of the Autism and Obsessive Compulsive Spectrum Program and the Anxiety and Depression Program at Montefiore Medical Center and the Albert Einstein College of Medicine, New York.

Barbara O. Rothbaum, Ph.D., A.B.P.P, is Professor of Psychiatry and Behavioral Sciences at Emory University School of Medicine in Atlanta, Georgia.

Dan J. Stein, M.D., is Professor and Chair of the Department of Psychiatry and Mental Health at the University of Cape Town, South Africa, Director of the South African Medical Research Council's Unit on Anxiety and Stress Disorders, and Visiting Professor at Mt. Sinai Medical School in New York.

This is a well-organized and incredibly comprehensive text which will serve as a tremendous resource for mental health practitioners. The authors, all highly respected and well- known experts in the field, update the reader with the latest advances in research and clinical practice for anxiety, trauma, and OCD and give the reader the knowledge needed to optimize the treatment efficacy of these disorders. This is a must have resource for mental health clinicians, educators, students and researchers alike.—Beth Salcedo, M.D., Past President, The Anxiety and Depression Association of America, Medical Director, The Ross Center for Anxiety and Related Disorders

This textbook is a clinician's best friend for anyone who wants to have the best and most up to date compendium of research and evidence-based theory about anxiety disorders, OCD and trauma related disorders. The editors have skillfully gathered together the top experts in every important aspect of understanding and treating these disorders. Reading this text will be like having a fascinating conversation with all of the top scientists and thinkers in the field anxiety, trauma and OCD.—Karen Lynn Cassiday, Ph.D., ACT, The Anxiety Treatment Center of Greater Chicago, Past President, Anxiety and Depression Association of America

This updated, third edition is an essential text and reference for all clinicians working with, or learning about, anxiety disorders. The content spans from the micro-level of individual human genes, to the macro-level of culture; from childhood to older adulthood; from pharmacologic strategies for individual diagnoses to psychotherapeutic approaches that may be applied in a unified protocol for all anxiety disorders. With chapters contributed by the world's foremost experts, the editors have compiled all the latest need-to-know information about the nature of anxiety disorders and how to best treat them.  This volume won't have a place on my bookshelf; it will be sitting open on my desk.Risa B. Weisberg, Ph.D., Assistant Chief of Psychology, VA Boston Healthcare System; Professor of Psychiatry, Boston University; Board of Directors, the Anxiety and Depression Association of America and the Association for Behavioral and Cognitive Therapies

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