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Clinical Manual of Addiction Psychopharmacology, Second Edition

Edited by Henry R. Kranzler, M.D., Domenic A. Ciraulo, M.D., and Leah R. Zindel, R.Ph., M.A.L.S.

  • ISBN 978-1-58562-440-9
  • Item #62440

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Clinical Manual of Addiction Psychopharmacology is a comprehensive guide to the pharmacology of drugs of abuse and the medications used to treat dependence on those substances. This new, second edition provides a thorough update on a broad range of addictive substances, along with enhanced coverage in areas where significant advances have been made since publication of the first edition. Clinicians, including psychiatrists, psychiatric residents and fellows, and other mental health practitioners who encounter individuals with substance-related disorders in the course of their clinical work, will find the manual to be well-organized, exhaustively referenced, and current.

The book is structured for ease of use and completeness of coverage, with an abundance of beneficial features:

  • Material is presented in a systematic fashion, addressing epidemiology, pharmacology of the abused substance (including pharmacokinetics and pharmacodynamics), psychopharmacological treatments, and issues of dependence, tolerance, withdrawal, and abstinence.
  • Both basic science and clinical dimensions are addressed, and these different perspectives, including pharmacotherapy and the psychosocial aspects of treatment, are integrated to allow clinicians a more holistic and effective treatment approach.
  • Coverage of the pharmacology of drugs of abuse is thorough and reflects the latest research findings, providing a necessary background for understanding the clinical effects and treatment of dependence on these substances.
  • Coverage of pharmacotherapy for dependence on these drugs is equally comprehensive, with meticulously detailed findings and evidence-based recommendations for the clinical care of patients dependent on a variety of substances.
  • Tables are used strategically to present complex information in a logical and accessible way; for example, the table on management of alcohol withdrawal syndrome includes detailed information on the symptom-triggered approach, fixed dose schedules, and delirium in a condensed, yet easy-to-understand format.

The book is well written and edited for clarity and accuracy by editors and contributors at the forefront of the psychopharmacology of addiction. As new drugs come into the market and old drugs find new applications, clinicians must stay current to provide the best care. Clinical Manual of Addiction Psychopharmacology helps them to do just that, offering both sound science and clinical wisdom to meet the complex challenges of treating individuals with substance-related disorders.


  • Contributors
  • Preface
  • Chapter 1. Alcohol
  • Chapter 2. Tobacco
  • Chapter 3. Opioids
  • Chapter 4. Cannabis
  • Chapter 5. Stimulants
  • Chapter 6. Sedatives, Hypnotics, and Anxiolytics
  • Chapter 7. Hallucinogens and Related Drugs
  • Chapter 8. Inhalants
  • Chapter 9. Club Drugs and Synthetic Cannabinoid Agonists
  • Chapter 10. Treatment of Substance Use Disorders
  • References
  • Index


    Domenic A. Ciraulo, M.D.
    Steven Epstein, M.D.
    Tony P. George, M.D., F.R.C.P.C.
    John H. Halpern, M.D.
    Carlos Hernandez-Avila, M.D., Ph.D.
    Kyle M. Kampman, M.D.
    Clifford M. Knapp, Ph.D.
    Henry R. Kranzler, M.D.
    David M. Ledgerwood, Ph.D.
    Frances R. Levin, M.D.
    John J. Mariani, M.D.
    James R. McKay, Ph.D.
    Cheryl A. Oncken, M.D., M.P.H.
    Torsten Passie, M.D., M.A.
    Nancy M. Petry, Ph.D.
    John A. Renner Jr., M.D.
    Richard N. Rosenthal, M.D.
    Ramon Solhkhah, M.D.
    Leah R. Zindel, R.Ph., M.A.L.S.

About the Authors

Henry R. Kranzler, M.D., is Professor of Psychiatry in the Department of Psychiatry at the Perelman School of Medicine of the University of Pennsylvania and Co-Associate Director of Research of the Mental Illness, Research, Education, and Clinical Center of the Philadelphia VAMC in Philadelphia, Pennsylvania.

Domenic A. Ciraulo, M.D., is Professor and Chairman of the Department of Psychiatry at Boston University School of Medicine, and Psychiatrist-in-Chief at Boston Medical Center in Boston, Massachusetts.

Leah R. Zindel, R.Ph., M.A.L.S., is a pharmacist and medical writer and editor in Philadelphia, Pennsylvania.

Kranzler, Ciraulo and Zindel's incredibly thorough, yet compact clinical manual of addiction pharmacology is a must for physicians and other providers who treat individuals with addictive disorders. Covering a wide range of topics from alcohol use disorders, prescription drug abuse, and synthetic cannabinoid agonists, to name a few, the guide is clearly written and well organized. The manual provides clear synopses of scientific studies for pharmacologic treatments, including the latest on pharmacogenetics, while offering practical advice for clinicians. This manual would serve as an excellent teaching tool for residents in advanced training for Addiction Psychiatry and/or American Board of Addiction Medicine fellowships. Overall, this manual offers much to both experienced professionals and those beginning a career in addiction medicine.—Ismene L. Petrakis M.D., Professor of Psychiatry, Yale School of Medicine; Chief of Psychiatry, VA Connecticut Healthcare System; Director, Addiction Psychiatry Fellowship, Yale School of Medicine

This is a condensed, thorough review of the current scientific and clinical research into treatment for addictive disorders. Although the focus is on psychopharmacological interventions, the book also considers psychosocial interventions. It gathers a wealth of relevant information in one place, making it a valuable reference for both new and seasoned clinicians in the field.—Michael Easton, M.D., Doody's Book Review

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