As the official Journal of the American Neuropsychiatric Association, the society of psychiatrists working at the interface between neuroscience and behavioral disorders, The Journal of Neuropsychiatry and Clinical Neurosciences is dedicated to advancing effective diagnosis and treatment options for patients with neuropsychiatric disorders. The Journal of Neuropsychiatry and Clinical Neurosciences publishes peer-reviewed articles addressing critical research areas such as Alzheimer's disease, traumatic brain injury, Parkinson's disease, epilepsy, and seizure disorders, and is devoted to reporting discoveries in clinical neuroscience that are relevant to understanding the brain-based disorders of patients. The journal features original articles, concisely written clinical and research reports, perspectives on emerging trends in the field, and classic pieces from the field's rich history. Each issue commences with the latest from the outstanding signature section "Windows to the Brain."

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In This Issue: Winter 2013

Update on Mild Traumatic Brain Injury: Neuropathology and Structural Imaging
In this installment of the Windows to the Brain series, the authors present detailed, graphic representation of neuronal injury for all levels of traumatic brain injury (TBI), including mild. We see representation of the swollen axon profiles characteristic of the “diffuse axonal injury” that produces transient focal deformations resulting from applied forces such as angular acceleration, pressure, and ballistic trauma, and, over time, the localized swelling that can become sufficient to rupture the axon. A challenge for the clinical follow-up of mild TBI is the presence of considerable differences across patients in the anatomic distribution of affected areas.

Hippocampal Volumes in Patients With Chronic Combat-Related Posttraumatic Stress Disorder: A Systematic Review
Recent research has demonstrated that veterans with chronic combat-related PTSD have a twofold increased risk of developing dementia. This review of current literature details neuroanatomical differences between veterans with PTSD and control subjects, some of whom have also had combat experience. The most common and consistent difference was in size of the hippocampus, which was found to be smaller in PTSD patients. There is a hypothesis that smaller hippocampal area is associated with greater risk for dementia; however, an alternate hypothesis is that a smaller hippocampus predisposes to PTSD.

Initial Treatment Retention in Psychogenic Non-Epileptic Seizures
The authors investigated factors relevant to treatment retention and initial adherence in patients with psychogenic non-epileptic seizures. The factors studies were 1) treatment modality, that is, whether psychotherapy and neuropsychiatric management were provided in the same institution or at a different location, and 2) subject characteristics. Modes of treatment provided at the same location yielded greater compliance than “divided intervention,” where subjects attended different settings for each approach. Subjects with cognitive complaints and those on anti-epileptic drugs showed lower compliance rates, whereas married subjects showed greater compliance.

Editorial Board

Editor
Stuart C. Yudofsky, M.D.

Deputy Editor
Robert E. Hales, M.D., M.B.A.

Assistants to the Editors
Claudia Burns, M.A., LPC
Andrea Lynn Sanders, AAS

Consulting Editors
Floyd Bloom, M.D.
Edward G. Jones, M.D., Ph.D.
Eric R. Kandel, M.D.
Henry Nasrallah, M.D.
Solomon H. Snyder, M.D.

Associate Editors
Nancy C. Andreasen, M.D., Ph.D.
David B. Arciniegas, M.D.
Nashaat N. Boutros, M.D.
C. Edward Coffey, M.D.
Joseph T. Coyle, M.D.
Jeffrey L. Cummings, M.D.
Michael Ebert, M.D.
Dwight L. Evans, M.D.
Robert C. Green, M.D.
Edward C. Lauterbach, M.D.
Thomas W. McAllister, M.D.
John M. Morihisa, M.D.
Charles Nemeroff, M.D., Ph.D.
Thomas C. Neylan, M.D.
Trevor R. P. Price, M.D.
Robert G. Robinson, M.D.
Stephen Salloway, M.D., M.S.
Randolph B. Schiffer, M.D.
Jonathan M. Silver, M.D.
Robert Stern, Ph.D.
Paula T. Trzepacz, M.D.
Daniel R. Weinberger, M.D.

Neuropsychiatric Practice and Opinion Editor
Fred Ovsiew, M.D.

Neuropsychiatry Classics Editor
Thomas C. Neylan, M.D.

Book Review Editor
Paula T. Trzepacz, M.D.

Windows to the Brain Editors
Robin A. Hurley, M.D.
L. Anne Hayman, M.D.
Katherine H. Taber, Ph.D.

Research and Statistical Design Consultants
Douglas Mossman, M.D.
Eugene Somoza, M.D., Ph.D.

Stuart C. Yudofsky, M.D., is the D.C. and Irene Ellwood Professor and Chairman of the Menninger Department of Psychiatry and Behavioral Sciences of Baylor College of Medicine, Adjunct Professor with MD Anderson Cancer Center, and Chairman of the Psychiatry Department of The Methodist Hospital. He is also responsible for oversight of academic activities in psychiatry at the Menninger Clinic the Ben Taub General Hospital and the Texas Children's Hospital.

Robert E. Hales, M.D., M.B.A., is the Joe P. Tupin Chair of the Department of Psychiatry and Behavioral Sciences and Interim Director of the M.I.N.D. Institute at the University of California, Davis School of Medicine in Sacramento, California.