The American Psychiatric Publishing Textbook of Psychopharmacology is now updated to keep you abreast of the latest research and trends in the field. Covering both basic science and clinical practice, this new edition draws on the talents of 53 new contributors—with the total increased from 139 to 158—to guarantee fresh, authoritative perspectives on advances in psychiatric drug therapy.
Introductory chapters provide a theoretical grounding in clinical applications, with coverage ranging from neurotransmitters to clinical trial design. The "Classes of Psychiatric Treatment" section is a virtual pharmacopoeia, with chapters devoted to specific agents. It presents information by class of drug, and for each agent provides data on indications, side effects, interactions, and more—including drugs likely to become available in the near future. Chapters in the "Clinical Psychobiology and Psychiatric Syndromes" section review the neurological underpinnings of specific disorders, providing a context for understanding psychopharmacological approaches to treatment. Coverage of those treatments encompasses state-of-the-art approaches to psychiatric disorders; specific patient populations, such as children and pregnant women; difficult-to-manage conditions like insomnia; and specific guidance on drug selection and prescription. Among the features of the fourth edition are the following
- A new chapter on genomics and genetics covers basic methodologies and concepts to help you interpret the avalanche of data appearing in the human neuroscience literature.
- Expanded chapters address newly approved agents, including the antidepressant desvenlafaxine, the antipsychotic paliperidone, and the anticonvulsant pregabalin.
- A new chapter on the neurobiology of childhood disorders considers data relating to pervasive developmental disorders, psychoses, learning disorders, disruptive behavior disorder/ADHD, bipolar disorder, major depressive disorder, obsessive-compulsive disorder/Tourette’s syndrome, PTSD, and pediatric anxiety disorders.
- A new chapter on treatment of chronic pain syndromes discusses major classes of medications as they relate to pain management and covers prevalent disorders—such as fibromyalgia and osteoarthritis—in which this is a priority and for which evidence-based therapy is available.
- A new, comprehensive review of ethical considerations in psychopharmacological treatment and research addresses such concerns as high-risk pharmacotherapy, long-acting medications, and off-label prescribing.
Solidly established as an authoritative and comprehensive source, the new edition of this new edition of The American Psychiatric Publishing Textbook of Psychopharmacology is even more indispensable for clinicians and researchers alike.
Introduction. Part I: Principles of Psychopharmacology. Neurotransmitters, receptors, signal transduction, and second messengers in psychiatric disorders. Basic principles of molecular biology and genomics. Genetics and genomics. Chemical neuroanatomy of the primate brain. Electrophysiology. Animal models. Psychoneuroendocrinology. Principles of pharmacokinetics and pharmacodynamics. Brain�immune system interactions: relevance to the pathophysiology and treatment of neuropsychiatric disorders. Brain imaging in psychopharmacology. Statistics, placebo response, and clinical trial design in psychopharmacology. Part II: Classes of Psychiatric Treatments: Animal and Human Pharmacology. Antidepressants and Anxiolytics. Tricyclic and tetracyclic drugs. Fluoxetine. Sertraline. Paroxetine. Fluvoxamine. Citalopram and s-citalopram. Monoamine oxidase inhibitors. Trazodone and nefazodone. Bupropion. Mirtazapine. Venlafaxine and desvenlafaxine. Duloxetine and milnacipran. Benzodiazepines. Buspirone and gepirone. Putative new-generation antidepressants. Antipsychotics. Classic antipsychotic medications. Clozapine. Olanzapine. Quetiapine. Aripiprazole. Risperidone and paliperidone. Ziprasidone. Drugs to treat extrapyramidal side effects. Drugs for Treatment of Bipolar Disorder. Lithium. Valproate. Carbamazepine and oxcarbazepine. Gabapentin and pregabablin. Lamotrigine. Topiramate. Other Agents. Cognitive enhancers. Sedative-hypnotics. Psychostimulants and wakefulness-promoting agents. Electroconvulsive therapy. Part III: Clinical Psychobiology and Psychiatric Syndromes. Neurobiology of mood disorders. Neurobiology of schizophrenia. Neurobiology of anxiety disorders. Neurobiology of Alzheimer’s disease. Neurobiology of substance abuse and addiction. Neurobiology of eating disorders. Neurobiology of personality disorders. Neurobiology of childhood disorders. Part IV: Psychopharmacological Treatment. Treatment of depression. Treatment of bipolar disorder. Treatment of schizophrenia. Treatment of anxiety disorders. Treatment of agitation and aggression in the elderly. Treatment of substance-related disorders. Treatment of eating disorders. Treatment of insomnia. Treatment of personality disorders. Treatment of psychiatric emergencies. Treatment of childhood and adolescent disorders. Psychopharmacology during pregnancy and lactation. Treatment during late life. Treatment of chronic pain syndromes. Part V: Ethical Issues. Ethical considerations in psychopharmacological treatment and research. Index.
"This book is laid out well, easy to use and reference, and stylistically pleasing. The information is comprehensive, practical, and useful, and its chapters are meticulously researched and referenced. Access to the online version of the book, which is available with the purchase of this edition, makes it easier and much more practical to use as a reference."—Steven T. Herron, M.D., Doody Enterprises, Inc.
Marilyn S. Albert, Ph.D.
Rebecca S. Allen, Ph.D.
David Ames, B.A., M.D., F.R.C.Psych., F.R.A.N.Z.C.P.
J. Wesson Ashford, M.D., Ph.D.
Erin D. Bigler, Ph.D.
Malaz Boustani, M.D., M.P.H.
Adam Boxer, M.D., Ph.D.
Carol Brayne, M.Sc., M.D.
John C.S. Breitner, M.D., M.P.H.
Mary E. Bret, M.D.
Katharina B�rger, M.D.
Louis D. Burgio, Ph.D.
Stephen Campbell, F.R.A.C.P., M.Ch.B.S., B.Sc.
Danielle China, M.S.
Edmond Chiu, A.M., M.B.B.S., D.P.M., F.R.A.N.Z.C.P.
C. Munro Cullum, Ph.D., A.B.P.P.
Martin R. Farlow, M.D.
Norman L. Foster, M.D.
Lawrence A. Frolik, J.D., L.L.M.
Dolores Gallagher-Thompson, Ph.D., A.B.P.P.
James E. Galvin, M.D., M.P.H.
Robert Garrett, M.D.
Yonas E. Geda, M.D., M.Sc.
David S. Geldmacher, M.D.
Harald-J�rgen Hampel, M.D., M.Sc.
Michelle M. Hilgeman, M.A.
Jason Holland, M.S.
Julian C. Hughes, M.A., M.B., Ch.B., M.R.C.Psych.,
Laura H. Lacritz, Ph.D., A.B.P.P.
Anne M. Lipton, M.D., Ph.D.
Katy H. Lonergan, M.S.
Constantine G. Lyketsos, M.D., M.H.S.
Selamawit Negash, Ph.D.
Ronald C. Petersen, Ph.D., M.D.
Mary Quiceno, M.D.
Roger N. Rosenberg, M.D.
Craig D. Rubin, M.D.
Mary Sano, Ph.D.
George M. Savva, Ph.D.
Joyce Simard, M.S.W.
Martin Steinberg, M.D.
Cassandra E.I. Szoeke, Ph.D., F.R.A.C.P., M.B.B.S.,
Pierre N. Tariot, M.D.
Ariz Rawan Tarawneh, M.D.
Ladislav Volicer, M.D., Ph.D., F.A.A.N., F.G.S.A.
Myron F. Weiner, M.D.
Roy Yaari, M.D.
Edward Zamrini, M.D.
Alan F. Schatzberg, M.D., is Kenneth T. Norris Jr. Professor and Chair of the Department of Psychiatry and Behavioral Sciences at Stanford University School of Medicine in Stanford, California.
Charles B. Nemeroff, M.D., Ph.D., is Reunette W. Harris Professor in the Department of Psychiatry and Behavioral Sciences at Emory University School of Medicine in Atlanta, Georgia.