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Obsessive-Compulsive Spectrum Disorders

Obsessive-Compulsive Spectrum Disorders
Refining the Research Agenda for DSM-V

Eric Hollander, M.D., Joseph Zohar, M.D., Paul J. Sirovatka, M.S., and Darrel A. Regier, M.D., M.P.H.
2011
257 pages
ISBN 978-0-89042-659-3
Paperback Also Available In: eBook
Item #2659



The five-year process of preparing for the revision of the Diagnostic and Statistical Manual (DSM) has been organized around a series of conferences convened by the American Psychiatric Association, in collaboration with the World Health Organization and the U.S. National Institutes of Health, to address the future of psychiatric diagnosis. Obsessive-Compulsive Spectrum Disorders: Refining the Research Agenda for DSM-V is the fruit of one of those conferences and presents the most academically sound, thought-provoking, and timely papers from the proceedings.

As the conference and book demonstrate, recent advances in psychiatric diagnosis suggest a new approach to obsessive-compulsive disorder (OCD) classification:


  • Research into the pathogenesis of OCD increasingly supports reclassification out of the anxiety disorders and into a separate group of obsessive-compulsive-related disorders (OCRDs).
  • The relationships among OCRDs may be better defined, delineated, and understood if the current categorical diagnostic approach is supplemented with a dimensional approach which assesses obsessive-compulsive symptom domains.
  • Obsessive-compulsive disorders are believed to be underdiagnosed in patients who complain of broad symptoms of anxiety, and reclassification of OCD as an OCRD would promote more careful examination of distinct obsessive-compulsive symptoms, yield more accurate diagnosis, and result in more effective treatments.
  • Reclassification may facilitate future research directions in examining the biological underpinnings of these disorders.

In addition to examining the genetic, neurological, and ethno-cultural bases for OCRDs, the book gives special attention to disorders that cross current diagnostic categories, including:


  • Body dysmorphic disorder (BDD)
  • Tourette’s syndrome and trichotillomania
  • Impulse-control disorders

The process leading to publication of DSM-V is by its nature an exhaustive and complex one, and the conferences play a critical role in reviewing relevant research, assessing the status of scientific knowledge, and advancing that knowledge base. Obsessive-Compulsive Spectrum Disorders: Refining the Research Agenda for DSM-V represents the cutting-edge thinking that will culminate in new diagnoses, classifications, and standards of practice for this debilitating set of disorders. Clinicians and academicians will be fascinated by this glimpse into the next generation of the DSM-V.

Preface. Introduction. Obsessive-compulsive disorder: boundary issues. Relationship of body dysmorphic disorder and eating disorders to obsessive-compulsive disorder. Tourette's syndrome, trichotillomania, and obsessive-compulsive disorder: how closely are they related? Relationship between impulse-control disorders and obsessive-compulsive disorder: a current understanding and future research directions. Symptom dimensions in obsessive-compulsive disorder: implications for DSM-V. Overview of genetics and obsessive-compulsive disorder. Neurological considerations: autism and Parkinson's disease. Cross-species models of obsessive-compulsive spectrum disorders. Obsessive-compulsive spectrum disorders: cross-national and ethnic issues. Index.

"This book presents the revised, comprehensive literature analyses discussed at a 2006 international expert’s conference aimed at informing DSM-V and ICD 11. The reader is treated to a wealth of information regarding the epidemiology, comorbidity patterns, genetics, neuroimaging results, and treatment response of the O-C Spectrum Disorders, including body dysmorphic disorder, Tourette’s disorder, eating disorders, trichotillomania, impulse control disorders and neurological conditions such as autism. Critical reviews of animal models, cross national issues and potential directions for future research crown this rich summary of current scientific knowledge."—Lorrin M. Koran, M.D., Professor of Psychiatry, Emeritus, Stanford University Medical Center


"The book provides an organized and well-written reflection of the conference proceedings concerning OCD and obsessive-compulsive spectrum disorders for DSM-5. The chapters give a comprehensive and up-to-date review of a large body of literature and flow easily."—Jessica Rasmussen, Ph.D. and Sabine Wilhelm, Ph.D., The American Journal of Psychiatry, 5/1/2012

Paul Arnold, M.D., Ph.D., FRCP
Vasileios Boulougouris, B.Sc., M.Phil., Ph.D.
Ashley Braun, B.A.
Samuel R. Chamberlain, M.D., Ph.D.
Kevin J. Craig, M.B.B.Ch., M.Phil, MRCPsych
Ygor Arzeno Ferr�o, M.D., Ph.D.
Naomi A. Fineberg, , M.B.B.S., M.A., MRCPsych
Eric Hollander, M.D.
Walter H. Kaye, M.D.
James L. Kennedy, M.D.
Suah Kim, M.S.
Lorrin M. Koran, M.D.
Nuria Lanzagorta, BSPSY
James F. Leckman, M.D.
Laura Marsh, M.D.
David Mataix-Cols, Ph.D.
Hisato Matsunaga, M.D., Ph.D.
Euripedes Constantino Miguel, M.D., Ph.D.
Gerald Nestadt, M.D., M.P.H.
Humberto Nicolini, M.D., Ph.D.
Stefano Pallanti, M.D., Ph.D.
Katharine A. Phillips, M.D.
Marc N. Potenza, M.D., Ph.D.
Scott L. Rauch, M.D.
Darrel A. Regier, M.D., M.P.H.
Trevor W. Robbins, Ph.D., FRS, FMedSci
Sanjaya Saxena, M.D.
Soraya Seedat, Ph.D., MBChB, FCPsych
Daphne Simeon, M.D.
Paul J. Sirovatka, M.S. (1947�2007)
Dan J. Stein, M.D., Ph.D.
A. Ting Wang, Ph.D.
Joseph Zohar, M.D.

Eric Hollander, M.D., is on the faculty in the Department of Psychiatry and Behavioral Sciences at Montefiore Medical Center and Albert Einstein College of Medicine in Bronx, New York.

Joseph Zohar, M.D., is Professor of Psychiatry in the Department of Psychiatry at Chaim Sheba Medical Center in Tel-Hashomer, Israel; and International Editor of CNS Spectrums.

Paul J. Sirovatka, M.S. (1947�2007), was Director of Research Policy Analysis in the Division of Research and American Psychiatric Institute for Research and Education at the American Psychiatric Association in Arlington, Virginia.

Darrel A. Regier, M.D., M.P.H., is Executive Director of the American Psychiatric Institute for Research and Education and Director of the Division of Research at the American Psychiatric Association in Arlington, Virginia.