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Schizophrenia is a common and frequently disabling illness that poses significant challenges to affected individuals, their families, mental health care providers, healthcare systems, and societies. Schizophrenia includes a group of psychotic disorders characterized by both positive and negative symptoms. These symptoms are associated with difficulty functioning in one or more areas, such as work, school, relationships, and self-care.

Positive symptoms of schizophrenia can include:

  • Delusions, which may be bizarre in nature
  • Hallucinations, especially auditory
  • Disorganized speech
  • Inappropriate affect
  • Disorganized behavior

Negative symptoms of schizophrenia can include:

  • Flat affect or lack of emotional response
  • Avolition or absence of initiative or goals
  • Alogia, speechlessness, or diminished flow of conversation
  • Anhedonia or inability to experience pleasure

Schizophrenia is most effectively treated through integrated care that takes into account the patient’s living environment, resources, and social circumstances, and includes a combination of antipsychotic medications and psychosocial treatments.

Essential Titles on Schizophrenia

American Psychiatric Publishing (APPI), a division of the American Psychiatric Association, publishes textbooks and clinical manuals that cover the latest advances in knowledge about schizophrenia and the development of new evidence-based treatment approaches.

The American Psychiatric Publishing Textbook on Schizophrenia

The American Psychiatric Publishing Textbook on Schizophrenia encompasses the current state of knowledge on the cause, nature, and treatment of this complex brain disease with contributions from experts in a wide range of disciplines.


Essentials of SchizophreniaEssentials of Schizophrenia focuses on the clinical essentials of schizophrenia, including epidemiology, manifestations of illness, comorbidities, and treatment strategies, in a succinct, easy-to-read format.
Clinical Manual for Treatment of Schizophrenia

Clinical Manual for Treatment of Schizophrenia provides a wide-ranging, empirically based review of assessment and treatment issues in schizophrenia, offered from a multicultural and patient-centered perspective

View a complete list of publications relating to schizophrenia.